ArticleBMC cardiovascular disorders2025
Correlation between the neutrophil-to-lymphocyte ratio and the 90-day all-cause mortality in patients with acute respiratory failure: a retrospective analysis based on the MIMIC-IV Database.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Associations of NLR, MLR, and (neutrophil + monocyte)/lymphocyte ratio with 30-day mortality in diabetic ICU patients with heart failure: A retrospective cohort study.International journal of cardiology. Heart & vasculature · 2026Article
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Abstract
introductionThis study aims to examine the impact of the neutrophil-to-lymphocyte ratio (NLR) on 90-day all-cause mortality in individuals suffering from acute respiratory failure (ARF).
methodsRetrospectively including ARF patients from the MIMIC IV database, we classified them into the survivor and non-survivor cohorts according to their 90-day all-cause mortality rate. Demographic information, comorbidity, laboratory parameters, and other indices were collected.
resultsA total of 3941 patients aged 65.0 years were enrolled in this. Multivariate COX regression analysis identified age(HR = 1.034, 95%CI:1.025-1.042,P < 0.001), history of chronic obstructive pulmonary disease(HR = 1.406, 95%CI:1.051-1.879,P = 0.022), history of hypertension(HR = 1.287, 95%CI:1.021-1.622,P = 0.032), history of type 2 diabetes mellitus(HR = 1.389, 95%CI:1.073-1.798,P = 0.013),history of coronary heart disease(HR = 2.138, 95%CI:1.639-2.788,P < 0.001), respiratory rate(HR = 1.043, 95%CI:1.026-1.01,P < 0.001), platelets (HR = 0.998, 95%CI: 0.997-0.999,P = 0.001), hemoglobin(HR = 0.859, 95%CI:0.820-0.901,P < 0.001), serum sodium (HR = 0.959, 95%CI:=0.041) and NLR(Q4, in comparison to Q1, HR = 1.627, 95%CI:1.167-2.268,P = 0.004) as independent predictors of the 90-day all-cause mortality rate. The relationship between NLR and mortality was observed to be non-linear(P-non-linear = 0.008) based on RCS curve analysis, with a threshold value of 12.8. A high NLR above this threshold was significantly associated with increased 90-day mortality rate after adjustment for covariates(HR = 1.535, 95%CI:1.196-1.968,P < 0.001).
conclusionThe role of NLR as a risk factor in predicting 90-day all-cause mortality in ARF patients highlights its potential clinical usefulness in assessing patient prognosis.
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