Evidence map›Paper›PMID 39966721›Full record

ArticleBMC gastroenterology2025

A prospective, quasi-experimental study on the efficacy of a novel double-headed endoscope cleaning brush for cleaning flexible endoscopes.

Rui Shen, Yaping Wu, Jiajun Lv, Qukai Liu, Weiyan Yao, Shu Chen, Dandan Liu, Huijun Xi, Yibo Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rui Shen *Center of Endoscopy, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200000, China.
Yaping Wu *Department of Gastroenterology, School of Medicine, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, 200000, China.
Jiajun LvDepartment of Gastroenterology, School of Medicine, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, 200000, China.
Qukai LiuCenter of Endoscopy, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200000, China.
Weiyan YaoCenter of Endoscopy, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200000, China.
Shu ChenDepartment of Gastroenterology, School of Medicine, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, 200000, China.
Dandan LiuMedical Department, Changhai Hospital, Naval Medical University, Shanghai, 200000, China.
Huijun XiMedical Department, Changhai Hospital, Naval Medical University, Shanghai, 200000, China. xhj_cn@126.com.
Yibo ZhangDepartment of Hospital Infection Management, School of Medicine, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, 200000, China. zyb21452@rjh.com.cn.

Funding

the Shanghai Nursing Society No. 2018MS-B14
6 · The paper itself

Abstract

backgroundThe most important step in endoscope retreatment is careful manual cleaning before disinfection. Selecting the proper brushes is critical to disinfection. The study investigated the effectiveness of a novel double-headed disposable brush for cleaning flexible gastrointestinal endoscopes.

methodsThis prospective, quasi-experimental study included endoscopes used in a first-class hospital between January 2020 and August 2021. The primary outcome was the change in the amount of bacteria determined using the relative light unit (RLU) value of adenosine triphosphate (ATP) fluorescence.

resultsA total of 267 endoscopes (131 double-headed brushes and 136 conventional ones) were included. The changes in RLU values of the ATP detection before and after brushing in the double-headed group were significantly higher than in the conventional group (ΔRLU, 116 (55, 251) vs. 76 (26, 181), P = 0.001). Similar results were observed in the subgroup analysis of colonoscopes, especially those with a 3.8-mm channel (ΔRLU, 115 (34, 265) vs. 52 (19, 199), P = 0.007), but not for gastroscopes (P = 0.363). Positive bacterial culture rates were higher in the double-headed/nylon brush end and double-headed/non-woven fabric end than in the single-headed brush (40.5% and 70.2% vs. 33.1%, P < 0.001). DISCUSSION: The results indicated the advantage of the novel double-headed disposable brush for flexible endoscope cleaning, and the nylon brush end may explain the advantage.

conclusionThe cleaning effect of the novel double-headed disposable brush for the flexible endoscope was better than the conventional one.

trial registrationNot applicable.

Indexed as

DisinfectionEndoscopes, GastrointestinalEquipment ContaminationDisposable EquipmentEquipment DesignFemaleGastroscopesHumansMaleMiddle AgedProspective StudiesBiofilmBrushEndoscopesPathogen transmissionSanitation

Identifiers

PMID39966721
PMCPMC11837676

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.