Evidence map›Paper›PMID 39966718›Full record

ArticleBMC gastroenterology2025

Clinical and demographic analysis of patients with colorectal cancer screened at a reference hospital in Southern Brazil: comparative study based on age (Retrospective cohort study).

Otavio de Carvalho Modaffar Al-Alam, Rafael Jose Vargas Alves, Adele Lanziani Fae, Camile Neves Cardoso, Jamille Rizzardi Lava, Joanna Palmeira Castro, Julia Signori, Larissa Grazziotin Claudino, Tales Barros Cassal Wandscheer, Victor Viecceli Villarinho and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Otavio de Carvalho Modaffar Al-AlamGraduate Program in Pathology, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil. otavioalam@gmail.com.
Rafael Jose Vargas AlvesDepartment of Internal Medicine, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil.
Adele Lanziani FaeUndergraduate Medicine Program, Lutheran University of Brazil (ULBRA), Canoas, Brazil.
Camile Neves CardosoUndergraduate Medicine Program, Lutheran University of Brazil (ULBRA), Canoas, Brazil.
Jamille Rizzardi LavaClinical Oncology Department, Hospital Santa Rita, Santa Casa Hospital, Porto Alegre, Brazil.
Joanna Palmeira CastroUndergraduate Medicine Program, Lutheran University of Brazil (ULBRA), Canoas, Brazil.
Julia SignoriClinical Oncology Department, Hospital Santa Rita, Santa Casa Hospital, Porto Alegre, Brazil.
Larissa Grazziotin ClaudinoUndergraduate Medicine Program, Lutheran University of Brazil (ULBRA), Canoas, Brazil.
Tales Barros Cassal WandscheerUndergraduate Medicine Program, Lutheran University of Brazil (ULBRA), Canoas, Brazil.
Victor Viecceli VillarinhoUndergraduate Medicine Program, Lutheran University of Brazil (ULBRA), Canoas, Brazil.
Affoue Prisca Michelle S YaoUndergraduate Medicine Program, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Claudia Giuliano BicaGraduate Program in Pathology, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is a prevalent and lethal malignancy. This study examines differences in clinical and prognostic characteristics of CRC between patients under 50 years and those aged 50 and above, treated at a reference hospital in Southern Brazil.

methodsA retrospective cohort study was conducted, analyzing data from the Cancer Hospital Registry in Porto Alegre, RS. Patients diagnosed with colon or rectal adenocarcinoma between January 2013 and December 2017 were included. Variables analyzed included family history, alcoholism, smoking status, clinical staging, tumor laterality, clinical presentation, CEA levels at diagnosis, adjuvant chemotherapy, and neutrophil-to-lymphocyte ratio.

resultsThe study cohort included 1,121 patients, with 85% aged 50 years or older, and 15% younger than 50 years. Significant differences were observed in smoking status and clinical presentation, with younger patients presenting with a higher prevalence of obstruction/subocclusion at diagnosis, which may reflect differences in clinical presentation due to delayed diagnosis.

conclusionsAge and lifestyle factors, particularly smoking, significantly influenced the clinical presentation and management of colorectal cancer. These findings underscore the importance of targeted prevention strategies and personalized treatment approaches for younger CRC patients.

Indexed as

AdenocarcinomaColonic NeoplasmsColorectal NeoplasmsAdultAgedAged, 80 and overAge FactorsBrazilCarcinoembryonic AntigenEarly Detection of CancerFemaleHumansMaleMiddle AgedNeoplasm StagingRetrospective StudiesCarcinoembryonic AntigenAge differencesClinical characteristicsColorectal cancerEpidemiologyRetrospective cohort studySouthern Brazil

Identifiers

PMID39966718
PMCPMC11837471

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.