ArticleScientific reports2025
Global, regional, and national trends in the burden of melanoma and non-melanoma skin cancer: insights from the global burden of disease study 1990-2021.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- MicroRNAs and Cellular Senescence in Melanoma: An Underexplored Link to Tumor Progression-A Systematic Review with Bioinformatics Analyses.International journal of molecular sciences · 2026Pooled it
- Conjunctival Ultraviolet Autofluorescence: A Systematic Review of Factors Affecting Observed Ocular Damage.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Pooled it
- Ethosome-based drug delivery system for precision targeting and tumour microenvironment reprogramming in non-invasive skin cancer therapy.Discover nano · 2026Review
- Advancing Electrochemotherapy in Melanoma and Non-Melanoma Skin Cancer: From Clinical Practice to Emerging Frontiers.International journal of molecular sciences · 2026Review
- Analysis of Melanoma Educational Content and Skin of Color Representation on TikTok: Cross-Sectional Study.JMIR dermatology · 2026Article
- Epidemiology of Non-Melanoma Skin Cancer in Europe over the Last Decade: A Systematic Review.Cancers · 2026Review
- Clinical Patterns in Patients with Basal Cell Carcinoma: A 10-Year Single-Center Retrospective Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Global skin cancer burden and United States mortality trends in younger adults (Aged 20-44 Years): An analysis of the Global Burden of Disease Study 2021 and CDC WONDER Databases.JID innovations : skin science from molecules to population health · 2026Article
- Illness Acceptance Among Adults with Melanoma: A Prospective Observational Cross-Sectional Study.Cancers · 2026Article
- A Silent Gap: Underrepresentation of Latin American Patients in Pivotal Genitourinary and Skin Cancer Trials.The oncologist · 2026Article
- Quantifying the Interplay Between PRAME Expression and Classical Morphology: A Multivariable Analysis of 954 Suspected Melanocytic Lesions.Dermatopathology (Basel, Switzerland) · 2026Article
- Time-Resolved Metabolomics Reveals Distinct, Cell- and Variety-Dependent Profiles of Prostanoids in Melanoma Cells Exposed to Fruit Extracts fromInternational journal of molecular sciences · 2026Article
- Automated Skin Lesion and Cancer Detection Using Computer Vision: A Comprehensive Review.Bioengineering (Basel, Switzerland) · 2026Review
- Routine Frozen Section Analysis May Be Omittable for Nodular Basal Cell Carcinoma Undergoing Local Flap Reconstruction.Cancers · 2026Article
- Numerical optimization of laser radius ratio and power in photothermal therapy of various ellipsoidal tumor shape.Discover nano · 2026Article
- In silico analysis of gene expression signatures and drug repurposing associated with metastatic progression in melanoma (skin cancer).Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Global Skin Cancer Burden From 1990 to 2023 and Projection to 2050.JAMA dermatology · 2026Article
- Differences in skin cancer-related beliefs and psychological distress among adults living in Florida who do and do not report a sunburn.Preventive medicine reports · 2026Article
- Translation of frozen sections into FFPE images for skin cancer resection margins using generative AI.NPJ digital medicine · 2026Article
- Immunohistochemical Analysis of pH-Sensitive TRPV5 in Common Skin Tumors.International journal of molecular sciences · 2026Article
Corrections and comments
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5 authors.
Funding
Abstract
This study examines global, regional, and national trends in melanoma and non-melanoma skin cancer (NMSC) burden from 1990 to 2021, their socioeconomic associations, and projects future trends. Data was extracted from the Global Burden of Disease (GBD) 2021 database, focusing on malignant melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). Joinpoint regression, age-period-cohort modeling, and decomposition analysis were used to assess temporal trends. The Socio-Demographic Index (SDI) was applied to examine the correlation between skin cancer burden and socioeconomic development, and ARIMA models forecasted future trends. The global burden of skin cancers has shown significant growth over the study period, with the age-standardized incidence rate (ASIR) rising globally (Estimated Annual Percentage Change, EAPC = 1.94%) from 1990 to 2021. This increase was particularly pronounced for BCC and SCC, while the melanoma DALYs rate declined (EAPC = -0.67%). In 2021, the most recent year covered, the global incidence of skin cancers was 6.64 million cases, with an ASIR of 77.66 per 100,000 and a disability-adjusted life years (DALYs) burden of 2.89 million cases. Significant geographic disparities were observed, with Australasia and North America reporting the highest ASIR, while middle-SDI regions exhibited rapid increases. Skin cancer incidence is rising globally, driven by demographic changes, increased UV exposure, and improved detection. The burden of melanoma has decreased, which may be related to advances in treatment. Targeted prevention, equitable access to care, and tailored regional strategies are crucial to mitigating the growing impact of skin cancers worldwide.
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