Evidence map›Paper›PMID 39966403›Full record

ArticleScientific reports2025

The Rhizophagus irregularis permease RiFTR1 functions without a ferroxidase partner for reductive iron transport.

Elisabeth Tamayo, Víctor Manuel López-Lorca, Chaeeun Shim, Olga López-Castillo, Araceli G Castillo, Natalia Requena, J Philipp Benz, Nuria Ferrol

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elisabeth TamayoDepartamento de Microbiología del Suelo y Sistemas Simbióticos, Estación Experimental del Zaidín, CSIC, Granada, Spain. tamayo@hfm.tum.de.
Víctor Manuel López-LorcaDepartamento de Microbiología del Suelo y Sistemas Simbióticos, Estación Experimental del Zaidín, CSIC, Granada, Spain.
Chaeeun ShimHolzforschung München, TUM School of Life Sciences, Technische Universität München, Freising, Germany.
Olga López-CastilloDepartamento de Microbiología del Suelo y Sistemas Simbióticos, Estación Experimental del Zaidín, CSIC, Granada, Spain.
Araceli G CastilloInstituto de Hortofruticultura Subtropical y Mediterránea "La Mayora", Universidad de Málaga-CSIC (IHSM, UMA-CSIC), Málaga, Spain.
Natalia RequenaMolecular Phytopathology, Botanical Institute, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
J Philipp BenzHolzforschung München, TUM School of Life Sciences, Technische Universität München, Freising, Germany.
Nuria FerrolDepartamento de Microbiología del Suelo y Sistemas Simbióticos, Estación Experimental del Zaidín, CSIC, Granada, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The contribution of arbuscular mycorrhizal fungi (AM fungi) to plant iron (Fe) acquisition has been demonstrated in several studies. A previous investigation revealed that the AM fungus Rhizophagus irregularis utilizes a high-affinity reductive pathway for Fe uptake, mediated by the Fe transporter RiFTR1. In this study, we used a genome-wide approach in R. irregularis to find genes encoding ferroxidases of the multicopper oxidase (MCO) gene family in an attempt to identify the ferroxidase partner of RiFTR1. Nine genes putatively encoding MCOs (RiMCO1-9) were identified. Yeast complementation assays demonstrated that RiMCO1 and RiMCO3 can function as ferroxidases, suggesting their involvement in the reductive Fe uptake pathway. Surprisingly, RiFTR1 was capable of transporting Fe in yeast without a ferroxidase partner, resembling the Fe transport mechanism of plant IRT1-like systems. RiFTR1 exhibited increase expression in arbuscules. Overexpression of RiFTR1 in Medicago truncatula roots led to enhanced mycorrhizal colonization and arbuscule abundance, highlighting the significance of Fe for AM symbiosis.

Indexed as

CeruloplasminFungal ProteinsGlomeromycotaIronMembrane Transport ProteinsBiological TransportFungiMedicago truncatulaMycorrhizaePlant RootsCeruloplasminFungal ProteinsIronMembrane Transport ProteinsArbuscular mycorrhizal symbiosisFerroxidasesFtr1 iron transporterHigh-affinity reductive pathwayRhizophagus irregularis

Identifiers

PMID39966403
PMCPMC11836134

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.