Evidence map›Paper›PMID 39966396›Full record

ArticleNature communications2025

A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis.

Pierre Raia, Kitaik Lee, Simon M Bartsch, Felix Rico-Resendiz, Daniela Portugal-Calisto, Oscar Vadas, Vikram Govind Panse, Dorothea Fiedler, Michael Hothorn

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. The Diphosphoinositol Polyphosphate Phosphohydrolase 1 family binds IPInternational journal of biological macromolecules · 2026
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pierre RaiaStructural Plant Biology Laboratory, Department of Plant Sciences, University of Geneva, Geneva, Switzerland.ORCID http://orcid.org/0000-0003-3469-1922
Kitaik LeeStructural Plant Biology Laboratory, Department of Plant Sciences, University of Geneva, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-7761-5586
Simon M BartschDepartment of Chemical Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.ORCID http://orcid.org/0000-0002-2215-7901
Felix Rico-ResendizStructural Plant Biology Laboratory, Department of Plant Sciences, University of Geneva, Geneva, Switzerland.
Daniela Portugal-CalistoInstitute of Medical Microbiology, University of Zürich, Zürich, Switzerland.
Oscar VadasProtein Biochemistry Platform, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID http://orcid.org/0000-0003-3511-6479
Vikram Govind PanseInstitute of Medical Microbiology, University of Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-4770-7068
Dorothea FiedlerDepartment of Chemical Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.ORCID http://orcid.org/0000-0002-0798-946X
Michael HothornStructural Plant Biology Laboratory, Department of Plant Sciences, University of Geneva, Geneva, Switzerland. michael.hothorn@unige.ch.ORCID http://orcid.org/0000-0002-3597-5698

Funding

Howard Hughes Medical Institute (HHMI) 55008733Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) CRSII5_209412
6 · The paper itself

Abstract

Inositol pyrophosphates (PP-InsPs) are eukaryotic nutrient messengers. The N-terminal kinase domain of diphosphoinositol pentakisphosphate kinase (PPIP5K) generates the messenger 1,5-InsP

Indexed as

PhosphatesPhosphoric Monoester HydrolasesPhosphotransferases (Phosphate Group Acceptor)Saccharomyces cerevisiae ProteinsArabidopsisArabidopsis ProteinsCatalytic DomainCrystallography, X-RayHomeostasisInositol PhosphatesModels, MolecularMutationProtein DomainsSaccharomyces cerevisiaeSignal TransductionSubstrate SpecificityArabidopsis Proteinsdiphosphoinositol pentakisphosphate kinaseInositol PhosphatesPhosphatesPhosphoric Monoester HydrolasesPhosphotransferases (Phosphate Group Acceptor)Saccharomyces cerevisiae Proteins

Identifiers

PMID39966396
PMCPMC11836120

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.