Evidence map›Paper›PMID 39966289›Full record

Observational studyDigestive diseases and sciences2025

Advanced Liver Fibrosis Impairs Cardiorespiratory Fitness in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease.

Miguel Sogbe, Breianna Hummer, Jonathan G Stine, Blanca Lizaola-Mayo, Daniel E Forman, Hugo E Vargas, Andres Duarte-Rojo

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Miguel SogbeLiver Unit, Clinica Universidad de Navarra, Pamplona, Spain.
Breianna HummerDivision of Gastroenterology & Hepatology, Department of Medicine, The Pennsylvania State University - Milton S. Hershey Medical Center, Hershey, PA, USA.
Jonathan G StineDivision of Gastroenterology & Hepatology, Department of Medicine, The Pennsylvania State University - Milton S. Hershey Medical Center, Hershey, PA, USA.
Blanca Lizaola-MayoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Phoenix, AZ, USA.
Daniel E FormanDivisions of Cardiology and Geriatrics, Department of Medicine, University of Pittsburgh, and the Pittsburgh Geriatrics, Research, Education and Clinical Center (GRECC), VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.
Hugo E VargasDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Phoenix, AZ, USA.
Andres Duarte-RojoDivision of Gastroenterology and Hepatology, Department of Medicine, Comprehensive Transplant Center, Northwestern Medicine, Feinberg School of Medicine, Northwestern University, 676 N. St. Clair St., Room 1900, Chicago, IL, USA. andres.duarte@northwestern.edu.

Funding

Penn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1M
Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Shuchang Silvia Liu · 2019 to 2026
$10.9M
Establishing the mechanism of benefit and dose of exercise required to improve liver histology in patients with nonalcoholic steatohepatitisK23DK131290 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI STINE, JONATHAN G · 2022 to 2025
$801k
NCATS NIH HHS UL1TR000127NIDDK NIH HHS K23 DK131290NIDDK NIH HHS K23DK131290NIDDK NIH HHS L30 DK118601NIDDK NIH HHS P30DK120531
6 · The paper itself

Abstract

backgroundMASLD is a leading reason for liver transplant waitlisting. The relationship between cardiorespiratory fitness (CRF) and liver fibrosis in patients with MASLD remains unclear. This study aims to provide further evidence supporting the relationship between liver fibrosis and CRF.

methodsParticipants with MASLD across various fibrosis stages, including those with cirrhosis awaiting liver transplantation from three U.S. transplant centers, underwent cardiopulmonary exercise testing (CPX). We compared participants based on fibrosis stage (F0-F1, F2-F3, and F4) and CPX parameters such as VO

resultsSixty-one participants underwent CPX testing across three centers. Participants with F4 had lower VO

conclusionsIn MASLD patients, advanced liver fibrosis, particularly cirrhosis, is associated with reduced CRF and poorer hemodynamic performance during CPX. Prioritizing exercise training for those in earlier stages (F3) may prevent fitness decline, which could hinder physical training and liver transplantation candidacy.

Indexed as

Cardiorespiratory FitnessFatty LiverLiver CirrhosisAdultAgedExercise TestFemaleHumansLiver TransplantationMaleMiddle AgedProspective StudiesCardiopulmonary exercise testingCirrhosisLiver transplantMetabolic dysfunction-associated steatotic liver disease

Identifiers

PMID39966289

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.