Evidence map›Paper›PMID 39966273›Full record

ArticleAnnals of surgical oncology2025

The Relationship Between Area-Level Marginalization and Overall Survival of Patients with Soft Tissue Sarcoma in Ontario: A Retrospective Cohort Study.

Vasiliki Tellios, Aaron Gazendam, Anthony Griffin, Jay Wunder, Kim Tsoi, Peter Ferguson

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Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vasiliki TelliosTemerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Aaron GazendamDivision of Orthopaedic Surgery, Department of Surgery, Sinai Health System, University of Toronto Musculoskeletal Oncology Unit, Toronto, ON, Canada. aaron.gazendam@gmail.com.ORCID http://orcid.org/0000-0002-2615-4919
Anthony GriffinDivision of Orthopaedic Surgery, Department of Surgery, Sinai Health System, University of Toronto Musculoskeletal Oncology Unit, Toronto, ON, Canada.
Jay WunderDivision of Orthopaedic Surgery, Department of Surgery, Sinai Health System, University of Toronto Musculoskeletal Oncology Unit, Toronto, ON, Canada.
Kim TsoiDivision of Orthopaedic Surgery, Department of Surgery, Sinai Health System, University of Toronto Musculoskeletal Oncology Unit, Toronto, ON, Canada.
Peter FergusonDivision of Orthopaedic Surgery, Department of Surgery, Sinai Health System, University of Toronto Musculoskeletal Oncology Unit, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSocioeconomic status and community marginalization can impact overall survival and functional outcome in patients with cancer. However, this association has not been determined in patients with soft tissue sarcoma (STS) within Canada. The primary aim of this study was to determine the impact of marginalization on STS 5-year overall survival. PATIENTS AND

methodsWe conducted a retrospective cohort study of patients presenting with primary or locally recurrent STS who underwent surgical resection between January 2010 and December 2021. Marginalization was determined using the Ontario Marginalization Index (ON-Marg), with subdomains including Ethnic Concentration, Material Resources, Household Dwelling, and Labor Dependency, and patients were stratified into quintiles (Q1 = least marginalized; Q5 = most marginalized). The association between marginalization and overall survival was determined using Kaplan-Meier curves and a multivariate Cox proportional hazards model.

resultsWhen adjusted for age and grade of disease, 5-year overall survival was not impacted by Ethnic Concentration (75.2% Q1 vs. 80.5% Q5). However, 5-year overall survival was significantly affected by increasing marginalization within Material Resources (81.9% Q1 vs. 69% Q5), Household Dwelling (82.2% Q1 vs. 69.6% Q5), and Labor Dependency (75.4% Q1 vs. 67.3% Q5). Significant differences across quintiles with regard to 1-year functional outcomes were noted with the Toronto Extremity Salvage Score, while nonsignificant changes were noted with the Musculoskeletal Tumor Society Score-93.

conclusionsThis study is the first to demonstrate marginalization as an independent risk factor adversely impacting 5-year overall survival of STS in Canada's single-payer universal healthcare system.

Indexed as

SarcomaSocial MarginalizationAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedOntarioPrognosisRetrospective StudiesSurvival RateMarginalizationSocioeconomic statusSoft tissue sarcoma

Identifiers

PMID39966273

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.