ArticleGeroScience2025
Center frequency as optimal frequency of visual stimulation for spreading entrained gamma rhythms to other target brain regions in cognitively normal older adults.
Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Sensory gamma entrainment in older adults with or without cognitive impairment: a systematic review and exploratory meta-analysis.GeroScience · 2026Review
- Neurobiological mechanisms of 40-Hz stimulation in Alzheimer's disease: evidence, heterogeneity, and constraints.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Association of glymphatic function with 40-Hz neural oscillations, systemic metabolic markers, and cognitive performance in healthy aging adults: An EEG and MRI study.Translational psychiatry · 2026Article
- Restoration of gamma center frequency via personalized entrainment marks cognitive preservation in early Alzheimer's disease.GeroScience · 2026Article
- Regular cannabis use modulates gamma functional connectivity with V1 during visual processing.NeuroImage · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Gamma entrainment using 40 Hz sensory stimulation has shown promise in AD mouse models, but inconsistent results in AD patients, possibly due to interspecies and interindividual differences in center frequency (CF). This study aimed to investigate whether gamma rhythms entrained by visual stimulation at an individual's CF can spread better than those at other frequency conditions in older adults. We entrained gamma rhythms in 32 cognitively normal older participants using light flickering at 32 Hz, 34 Hz, 36 Hz, 38 Hz, and 40 Hz. We identified each individual's CF among these five frequencies and compared the spread, strength, and stability of gamma connectivity induced by light stimulation flickering at an individual's CF with those at other frequencies using generalized estimating equation and repeated measures ANOVA. In about two-thirds of the participants, 32 Hz (40.6%) and 34 Hz (28.1%) were identified as CF. The mean spread, strength, and stability of gamma connectivity involving the visual cortex (GC
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Registered trials
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