Evidence map›Paper›PMID 39966243›Full record

ArticleJournal of natural medicines2025

Fungal protein D1 inhibits the proliferation of A549 cells via activating the p53/miR-34a signaling pathway.

Min-Hui Zhang, Fang Liu, Wen-Hui Gao, Zhao-Kun Liu

Abstract read
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Article in Journal of natural medicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Min-Hui Zhang *Department of Microbiology, The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin, 300071, China.
Fang Liu *Department of Microbiology, The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin, 300071, China.
Wen-Hui GaoDepartment of Microbiology, The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin, 300071, China.
Zhao-Kun LiuResearch Institute of Public Health, School of Medicine, Nankai University, Tianjin, 300071, China. 9920210063@nankai.edu.cn.

Funding

Fundamental Research Funds for the Central Universities, Nankai University 63221057Science and Technology Project of Hebei Education Department QN2024097
6 · The paper itself

Abstract

Boletus bicolor is a kind of wild edible boletus, which is widely distributed in China. We have isolated the protein D1 from B. bicolor, and found that protein D1 has a significant inhibitory effect on the growth and proliferation of lung cancer A549 cells both in vitro and in vivo. In this paper, we found that miR-34a plays an important role in inhibiting the proliferation of A549 cells. miR-34a is the functional target of protein D1 against A549 cells. Protein D1 induces the positive feedback regulation of miR-34a and p53, which further regulates downstream Bcl-2 and CDK6, and inhibits the proliferation of A549 cells.

Indexed as

Cell ProliferationMicroRNAsSignal TransductionTumor Suppressor Protein p53A549 CellsAnimalsHumansMiceMicroRNAsMIRN34 microRNA, humanTP53 protein, humanTumor Suppressor Protein p53A549 cellsBoletus bicolormiR-34ap53Protein D1

Identifiers

PMID39966243

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.