Evidence map›Paper›PMID 39966222›Full record

ArticleJournal of imaging informatics in medicine2025

Mainecoon: Implementing an Open-Source Web Viewer for DICOM Whole Slide Images with AI-Integrated PACS for Digital Pathology.

Chao-Wei Hsu, Si-Wei Yang, Yu-Ting Lee, Kai-Hsuan Yao, Tzu-Hsuan Hsu, Pau-Choo Chung, Yuan-Chia Chu, Chen-Tsung Kuo, Chung-Yueh Lien

Abstract read
In one paragraph

Article in Journal of imaging informatics in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Report on the 2025 DICOM WSI Connectathon.Journal of pathology informatics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chao-Wei HsuDepartment of Information Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Si-Wei YangDepartment of Information Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Yu-Ting LeeDepartment of Information Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Kai-Hsuan YaoDepartment of Information Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Tzu-Hsuan HsuDepartment of Information Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Pau-Choo ChungDepartment of Electrical Engineering, National Cheng Kung University, Tainan, Taiwan.
Yuan-Chia ChuDepartment of Information Management, Taipei Veterans General Hospital, Taipei, Taiwan.
Chen-Tsung KuoDepartment of Information Management, Taipei Veterans General Hospital, Taipei, Taiwan.
Chung-Yueh LienDepartment of Information Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan. chungyueh@ntunhs.edu.tw.ORCID http://orcid.org/0000-0002-7230-6303

Funding

National Science and Technology Council 112-2321-B-075-003National Science and Technology Council 112-2634-F-006-002
6 · The paper itself

Abstract

The rapid advancement of digital pathology comes with significant challenges due to the diverse data formats from various scanning devices creating substantial obstacles to integrating artificial intelligence (AI) into the pathology imaging workflow. To overcome performance challenges posed by large AI-generated annotations, we developed an open-source project named Mainecoon for whole slide images (WSIs) using the Digital Imaging and Communications in Medicine (DICOM) standard. Our solution incorporates an AI model to detect non-alcoholic steatohepatitis (NASH) features in liver biopsies, validated with the DICOM Workgroup 26 Connectathon dataset. AI-generated results are encoded using the Microscopy Bulk Simple Annotations standard, which provides a standardized method supporting both manual and AI-generated annotations, promoting seamless integration of structured metadata with WSIs. We proposed a method by leveraging streaming and batch processing, significantly improving data loading efficiency, reducing user waiting times, and enhancing frontend performance. The web services of the AI model were implemented via the Flask framework, integrated with our viewer and an open-source medical image archive, Raccoon, with secure authentication provided by Keycloak for OAuth 2.0 authentication and node authentication at the National Cheng Kung University Hospital. Our architecture has demonstrated robustness, interoperability, and practical applicability, addressing real-world digital pathology challenges effectively.

Indexed as

Artificial IntelligenceRadiology Information SystemsHumansInternetLiverNon-alcoholic Fatty Liver DiseaseDICOMDigital pathologyInteroperabilityOpen source

Identifiers

PMID39966222
PMCPMC12701149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.