Evidence map›Paper›PMID 39966205›Full record

ArticleJournal of molecular neuroscience : MN2025

Cdh23 Gene Mutation-Induced Vestibular Dysfunction in Mice: Abnormal Stereocilia Bundle and Otolith Development and Activation of p53/FoxO Signaling Pathway.

Lihuan Tang, Yuancheng Wu, Kai Zhang, Daoli Xie, Xiaojing Kuang, Lan Wang, Zehua Sun, Ruishuang Geng, Juan Hu, Yan Sun and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lihuan TangHearing and Speech Rehabilitation Institute, Special Education and Rehabilitation College, Binzhou Medical University, Yantai, 264000, Shandong, China.
Yuancheng WuHearing and Speech Rehabilitation Institute, Special Education and Rehabilitation College, Binzhou Medical University, Yantai, 264000, Shandong, China.
Kai ZhangHearing and Speech Rehabilitation Institute, Special Education and Rehabilitation College, Binzhou Medical University, Yantai, 264000, Shandong, China.
Daoli XieHearing and Speech Rehabilitation Institute, Special Education and Rehabilitation College, Binzhou Medical University, Yantai, 264000, Shandong, China.
Xiaojing KuangHearing and Speech Rehabilitation Institute, Special Education and Rehabilitation College, Binzhou Medical University, Yantai, 264000, Shandong, China.
Lan WangHearing and Speech Rehabilitation Institute, Special Education and Rehabilitation College, Binzhou Medical University, Yantai, 264000, Shandong, China.
Zehua SunHearing and Speech Rehabilitation Institute, Special Education and Rehabilitation College, Binzhou Medical University, Yantai, 264000, Shandong, China.
Ruishuang GengHearing and Speech Rehabilitation Institute, Special Education and Rehabilitation College, Binzhou Medical University, Yantai, 264000, Shandong, China.
Juan HuDepartment of Otorhinolaryngology, Head and Neck Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shanxi, China.
Yan SunDepartment of Otolaryngology and Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, 264000, Shandong, China. entsunyan@126.com.
Tihua ZhengHearing and Speech Rehabilitation Institute, Special Education and Rehabilitation College, Binzhou Medical University, Yantai, 264000, Shandong, China. iamnanni@126.com.
Bo LiHearing and Speech Rehabilitation Institute, Special Education and Rehabilitation College, Binzhou Medical University, Yantai, 264000, Shandong, China. liboyjt@163.com.
Qingyin ZhengHearing and Speech Rehabilitation Institute, Special Education and Rehabilitation College, Binzhou Medical University, Yantai, 264000, Shandong, China.

Funding

National Natural Science Foundation of China 81500797National Natural Science Foundation of China 81530030National Natural Science Foundation of China 82171143National Natural Science Foundation of China 82371137, 81873697Shandong Provincial Natural Science Foundation of China ZR2022MC149Shandong Provincial Natural Science Foundation of China ZR2023QH402Shandong Provincial Natural Science Foundation of China ZR2024MH263
6 · The paper itself

Abstract

Vestibular dysfunction (VD) is increasingly acknowledged as a significant contributor to falls and deterioration in health. Cadherin 23 (Cdh23) serves as an essential protein responsible for facilitating the mechanical transduction processes in hair cells, and variations in this gene have been recognized as possible factor to auditory impairments and VD. The gene Cdh23 encodes glycoproteins that play a role in cell adhesion and are crucial for the development of stereocilia bundles. In this research, we generated CDH23 functional null mice (Cdh23

Indexed as

CadherinsForkhead Transcription FactorsOtolithic MembraneStereociliaTumor Suppressor Protein p53Vestibular DiseasesAnimalsCadherin Related ProteinsMiceSignal TransductionCadherin Related ProteinsCadherinsCdh23 protein, mouseForkhead Transcription FactorsTumor Suppressor Protein p53Cdh23 V2J2/V2J2 miceOtolithsp53 and FoxO signaling pathwaysStereocilia bundlesVestibular dysfunctionVHCs

Identifiers

PMID39966205

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.