Evidence map›Paper›PMID 39966177›Full record

ArticleEuropean radiology2025

Leptomeningeal metastases at recurrence in IDH-wildtype glioblastomas: incidence, risk factors, and prognosis based on postcontrast FLAIR imaging.

Yae Won Park, Geon Jang, Si Been Kim, Kyunghwa Han, Na-Young Shin, Sung Soo Ahn, Jong Hee Chang, Se Hoon Kim, Rajan Jain, Seung-Koo Lee

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Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

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10 authors.

Yae Won ParkDepartment of Radiology and Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yonsei University College of Medicine, Seoul, Korea.
Geon JangDepartment of Industrial Engineering, Yonsei University, Seoul, Korea.
Si Been KimUndergraduate School of Biomedical Engineering, Korea University College of Health Science, Seoul, Korea.
Kyunghwa HanDepartment of Radiology and Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yonsei University College of Medicine, Seoul, Korea.
Na-Young ShinDepartment of Radiology and Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yonsei University College of Medicine, Seoul, Korea.
Sung Soo AhnDepartment of Radiology and Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yonsei University College of Medicine, Seoul, Korea. sungsoo@yuhs.ac.ORCID http://orcid.org/0000-0002-0503-5558
Jong Hee ChangDepartment of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
Se Hoon KimDepartment of Pathology, Yonsei University College of Medicine, Seoul, Korea.
Rajan JainDepartment of Radiology, New York University Grossman School of Medicine, New York, NY, USA.
Seung-Koo LeeDepartment of Radiology and Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yonsei University College of Medicine, Seoul, Korea.

Funding

Korea Medical Device Development RS-2023-00224382
6 · The paper itself

Abstract

objectivesTo comprehensively investigate the incidence, risk factors, and prognosis of leptomeningeal metastases (LM) diagnosed at recurrence in IDH-wildtype glioblastoma patients. MATERIALS AND

methodsA total of 734 IDH-wildtype glioblastoma patients were enrolled between 2005 and 2022. LM at recurrence was diagnosed with MRI including postcontrast FLAIR. Logistic analysis for development of LM at recurrence was performed with clinical, molecular, imaging (including tumor volume and distance to subventricular zone via automatic segmentation), and surgical data including extent of resection and ventricular entry. The overall survival (OS) was compared between patients with and without LM at recurrence.

resultsThe incidence of LM at recurrence based on postcontrast FLAIR was 10.8% (79 patients). On multivariable analysis, younger age at diagnosis (odds ratio (OR) = 0.98, p = 0.011) and ventricular entry (OR = 3.15, p < 0.001) were independent predictors of LM at recurrence. However, patients with LM at recurrence showed no significant difference in OS from patients without LM (log-rank test; p = 0.461), with median OS of 18.0 (95% confidence interval (CI) 16.2-19.8) and 18.5 (95% CI 16.4-20.7) months in patients with and without LM at recurrence, respectively.

conclusionThe incidence of LM at recurrence is relatively high in IDH-wildtype glioblastoma patients. Younger age and ventricular entry during surgery warrant imaging surveillance for LM at recurrence. As LM at recurrence showed no significant OS compromise and larger extent of resection (EOR) is associated with survival benefits, ventricular entry during maximal safe resection may be acceptable. KEY POINTS: Question The incidence, risk factors, and prognosis of leptomeningeal metastases (LM) diagnosed at recurrence in IDH-wildtype glioblastoma patients are currently unknown. Findings LM at recurrence occurred in 10.8% of cases, with younger age and ventricular entry as risk factors, but no significant difference in survival outcomes between groups. Clinical relevance The incidence, risk factors, and prognosis of LM at recurrence were investigated in IDH-wildtype glioblastoma patients with postcontrast FLAIR. Younger age and ventricular entry warrant surveillance of LM at recurrence, while the overall survival is not as discouraging as expected.

Indexed as

Brain NeoplasmsGlioblastomaMagnetic Resonance ImagingMeningeal NeoplasmsNeoplasm Recurrence, LocalAdultAgedContrast MediaFemaleHumansIncidenceIsocitrate DehydrogenaseMaleMiddle AgedPrognosisRetrospective StudiesContrast MediaIsocitrate DehydrogenaseGlioblastomaLeptomeningeal metastasesMagnetic resonance imagingPrognosisRisk factors

Identifiers

PMID39966177

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.