Evidence map›Paper›PMID 39966175›Full record

ArticleAnalytical and bioanalytical chemistry2025

Ratiometric surface-enhanced Raman scattering quantification of extracellular matrix metalloproteinase-2 activity for tumor diagnosis.

Dan Zhu, Hanyan Zhong, Jingzhan Shi, Qiang Liu, Yiping Wang

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dan ZhuInnovation Center of Intelligent Optoelectronic Sensing, School of Computer and Electronic Information/School of Artificial Intelligence, Nanjing Normal University, Nanjing, 210023, Jiangsu, People's Republic of China.
Hanyan ZhongInnovation Center of Intelligent Optoelectronic Sensing, School of Computer and Electronic Information/School of Artificial Intelligence, Nanjing Normal University, Nanjing, 210023, Jiangsu, People's Republic of China.
Jingzhan ShiInnovation Center of Intelligent Optoelectronic Sensing, School of Computer and Electronic Information/School of Artificial Intelligence, Nanjing Normal University, Nanjing, 210023, Jiangsu, People's Republic of China.
Qiang LiuInnovation Center of Intelligent Optoelectronic Sensing, School of Computer and Electronic Information/School of Artificial Intelligence, Nanjing Normal University, Nanjing, 210023, Jiangsu, People's Republic of China.
Yiping WangInnovation Center of Intelligent Optoelectronic Sensing, School of Computer and Electronic Information/School of Artificial Intelligence, Nanjing Normal University, Nanjing, 210023, Jiangsu, People's Republic of China. jeremy_ff@sina.com.

Funding

National Natural Science Foundation of China 61975082National Natural Science Foundation of China 62101269National Natural Science Foundation of China 62205149Natural Science Foundation of Jiangsu Province BK20200717Postgraduate Research & Practice Innovation Program of Jiangsu Province 181200003023203
6 · The paper itself

Abstract

As a precursor to cancer metastasis, the matrix metalloproteinase (MMP) family can degrade almost all protein components of the extracellular matrix, disrupting the histological barrier and promoting tumor invasion. Therefore, the sensitive and reliable detection of MMP activity in the tumor microenvironment is of great importance for the diagnosis and prognosis of malignant tumors. Here, a ratiometric surface-enhanced Raman scattering (SERS) sensing strategy based on interference-free internal standard was proposed for the accurate quantification of MMP-2 activity. A plasmonic substrate with core-satellite structure was constructed by self-assembly of silver nanoparticles on the gold core, which provided excellent SERS enhancement due to the coupling interaction. Besides, rhodamine B (RhB)-labelled substrate peptides and 4-mercaptobenzonitrile (MBN) were used as the MMP-2 recognizer and internal standard, respectively. MMP-2 specifically cleaved the peptides in half, leaving the RhB molecule free and the Raman signal at 1650 cm

Indexed as

Matrix Metalloproteinase 2NeoplasmsSpectrum Analysis, RamanCell Line, TumorGoldHumansLimit of DetectionMetal NanoparticlesSilverGoldMatrix Metalloproteinase 2MMP2 protein, humanSilverCore-satellite nanocompositeMatrix metalloproteinaseRatiometric detectionSurface-enhanced Raman scattering

Identifiers

PMID39966175

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.