ArticleIntensive care medicine2025
Persistent severe acute kidney injury is a major modifiable determinant of outcome during critical illness.
Article in Intensive care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Targeting integrated cell death networks in sepsis‑associated acute kidney injury: Shared regulatory nodes and diet‑related small molecule modulation (Review).International journal of molecular medicine · 2026Review
- What is the best dialysis regimen for severe AKI to allow kidney function recovery?Clinical kidney journal · 2026Review
- Dynamic Lactate-to-Albumin Ratio Trajectories and Outcomes in Sepsis-Associated Acute Kidney Injury: Evidence From MIMIC-IV and a Multicenter Chinese Cohort.JMIR medical informatics · 2026Observational
- Article
- Development and Validation of a Machine Learning-Based Risk Assessment Tool for In-Hospital Mortality in Elderly Patients with Postoperative Hypoxemia Following Non-Cardiac Surgery.Journal of clinical medicine · 2026Article
- Risk factors and nomogram prediction model for prognosis in sepsis with acute kidney injury.BMC nephrology · 2026Article
- HMGB1-mediated formation of IL-33-abundant NETs drives lung-to-kidney injury in severe pneumonia-associated acute kidney injury.JCI insight · 2026Article
- Transition from acute kidney injury to chronic kidney disease: molecular mechanisms and therapeutic interventions.Molecular biomedicine · 2026Review
- Sodium bicarbonate therapy for metabolic acidosis in children stratified by acute kidney injury status and chloride levels: a retrospective cohort study.Translational pediatrics · 2026Article
- The global epidemiology of acute kidney injury: challenges and opportunities.Nature reviews. Nephrology · 2026Review
- Clinical outcomes of persistent sepsis-associated acute kidney injury in septic shock: a post-hoc analysis of a multicenter prospective cohort study.Annals of intensive care · 2026Article
- The effects of hemoadsorption in patients with sepsis-associated persistent severe AKI who require CRRT: A prospective, randomized controlled pilot study.Annals of intensive care · 2026Article
- Early Identification and Risk Factors for Acute Kidney Injury Progression: A Real-World Study.Risk management and healthcare policy · 2026Article
- Four Distinct Dynamic Intracranial Pressure Trajectories and Their Prognostic Implications in Acute Brain Injury: A Multicenter Cohort Study.CNS neuroscience & therapeutics · 2026Article
- Utility of Restricted Mean Survival Time Analysis for Renal Replacement Therapy in Patients with Sepsis Associated Acute Kidney Injury: A Retrospective Study.International journal of general medicine · 2026Article
- Persistent Severe Acute Kidney Injury Among Critically Ill Patients: Outcomes and Predictive Markers-A Single-Center Retrospective Cohort Study.Critical care research and practice · 2026Article
- The prevalence and risk factors of acute kidney injury in post-orthopedic surgery patients.Frontiers in medicine · 2026Article
- Update on acute kidney injury: some progresses and a long way to go.Intensive care medicine · 2025Article
- Why interventions to prevent acute kidney injury are needed now and why preventing long-term outcomes will only come later.Intensive care medicine · 2025Article
- State of the art: Renal recovery after AKI - from basic science to clinical practice.Intensive care medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
rationaleMost cases of acute kidney injury (AKI) resolve within 72 h. However, a small number of patients with persistent severe AKI have significantly worse outcomes. We sought to describe the occurrence, impact on outcome and risk factors associated with persistent severe AKI in critically ill patients using a standardized definition.
methodsRetrospective cohort study, investigating critically ill patients admitted to one of 16 hospitals from October 2010 to June 2018. We defined persistent severe AKI as Kidney Disease: Improving Global Outcomes stage 2-3 AKI that progressed to and persisted at stage 3 for ≥ 72 h. Risk factors for persistent severe AKI and its association with outcomes were assessed using the super learner algorithm, integrating LASSO logistic regression and XGBoost, and multivariate logistic regression or Cox proportional hazards models, using no persistent severe AKI as the comparator. MEASUREMENTS AND MAIN
resultsOf 65,119/190,550 (34.2%) patients with stage 2-3 AKI, 8,059 (12.4%) had persistent severe AKI. Severe, early community-acquired AKI, high fluid balance, multiple organ dysfunction, sepsis and shock were important risk factors. Persistent severe AKI was associated with an increased risk of 90-day mortality (HR 1.5, 95% CI 1.4-1.6), hospital readmission (OR 2.0, 95% CI 1.8-2.3), and with a lower probability of renal recovery (OR 0.14, 95% CI 0.13, 0.15).
conclusionsPersistent severe AKI is an uncommon, but important complication in critically ill patients, associated with an increased risk of renal non-recovery, hospital readmission and death, and an important target for therapeutic development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.