Evidence map›Paper›PMID 39966140›Full record

ArticlePediatric nephrology (Berlin, Germany)2025

The incidence and outcome of acute kidney injury during pediatric kidney tumor treatment-a national cohort study.

Paulien A M A Raymakers-Janssen, Gerrit van den Berg, Marc R Lilien, Inge A van Kessel, Alida F W van der Steeg, Marc H W A Wijnen, Mieke I Triest, Sophie E van Peer, Marjolijn C J Jongmans, Harm van Tinteren and 4 more

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Article in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Paulien A M A Raymakers-JanssenDepartment of Pediatric Intensive Care, Wilhelmina Children's Hospital/University Medical Center Utrecht, Utrecht, The Netherlands. p.a.m.a.raymakers-janssen@umcutrecht.nl.ORCID 0000-0001-5227-2057
Gerrit van den BergPrincess Máxima Center for Pediatric Oncology and Wilhelmina Children's Hospital, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.
Marc R LilienDepartment of Pediatric Nephrology, Wilhelmina Children's Hospital/University Medical Center Utrecht, Utrecht, The Netherlands.
Inge A van KesselDepartment of Pediatric Intensive Care, Wilhelmina Children's Hospital/University Medical Center Utrecht, Utrecht, The Netherlands.
Alida F W van der SteegPrincess Máxima Center for Pediatric Oncology and Wilhelmina Children's Hospital, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.
Marc H W A WijnenPrincess Máxima Center for Pediatric Oncology and Wilhelmina Children's Hospital, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.
Mieke I TriestPrincess Máxima Center for Pediatric Oncology and Wilhelmina Children's Hospital, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.
Sophie E van PeerPrincess Máxima Center for Pediatric Oncology and Wilhelmina Children's Hospital, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.
Marjolijn C J JongmansPrincess Máxima Center for Pediatric Oncology and Wilhelmina Children's Hospital, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.
Harm van TinterenPrincess Máxima Center for Pediatric Oncology and Wilhelmina Children's Hospital, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.
Geert O JanssensPrincess Máxima Center for Pediatric Oncology and Wilhelmina Children's Hospital, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.
Marta FioccoPrincess Máxima Center for Pediatric Oncology and Wilhelmina Children's Hospital, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.
Roelie M Wösten-van AsperenDepartment of Pediatric Intensive Care, Wilhelmina Children's Hospital/University Medical Center Utrecht, Utrecht, The Netherlands.
Marry M van den Heuvel-EibrinkPrincess Máxima Center for Pediatric Oncology and Wilhelmina Children's Hospital, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) is a serious complication of pediatric cancer treatment that is suggested to increase the risk of chronic kidney disease (CKD). Children with a kidney tumor may be at particular risk. This study aimed to determine the incidence and risk factors of AKI and its association with CKD during pediatric kidney tumor treatment.

methodsWe analyzed data from a prospective national cohort of patients ≤ 18 years old diagnosed with a kidney tumor between 2015 and 2021 in the Princess Máxima Center for Pediatric Oncology in the Netherlands. AKI was defined according to KDIGO criteria. CKD was assessed 1 year post-treatment based on proteinuria and/or decreased estimated glomerular filtration rate (eGFR).

resultsOf 147 patients, we observed AKI in 104 patients (71%) during therapy. AKI occurred most often within 48 h after tumor nephrectomy (88/104), while the rest had non-nephrectomy-related AKI from multifactorial causes. Sixteen patients experienced more than one AKI episode, and 92/104 episodes were reversible. Patients who developed AKI had a higher eGFR prior to surgery compared to those who did not develop AKI. CKD was observed in 16/120 patients (13%). Risk factors for developing CKD included the occurrence of at least 1 AKI event, the use of a > 3-drug regimen, and a lower eGFR at the start of treatment.

conclusionThe high incidence of AKI and its association with early CKD highlights the need for early detection, prevention, and intervention strategies during pediatric kidney tumor treatment.

Indexed as

Acute Kidney InjuryKidney NeoplasmsNephrectomyRenal Insufficiency, ChronicAdolescentChildChild, PreschoolFemaleGlomerular Filtration RateHumansIncidenceInfantMaleNetherlandsProspective StudiesRisk FactorsAcute kidney injuryChronic kidney diseaseKidney tumorsWilms tumor

Identifiers

PMID39966140
PMCPMC12116620

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.