Evidence map›Paper›PMID 39966119›Full record

Observational studyJournal of gastroenterology2025

Clinical impact of epithelial types on postoperative outcomes for intraductal papillary mucinous neoplasms: a multicenter retrospective study.

Daiki Yamashige, Susumu Hijioka, Yasuhiro Shimizu, Akio Yanagisawa, Masafumi Nakamura, Kazuo Hara, Masayuki Kitano, Shinsuke Koshita, Tetsuya Takikawa, Toshifumi Kin and 10 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Daiki YamashigeDepartment of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan.
Susumu HijiokaDepartment of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan. shijioka@ncc.go.jp.ORCID 0000-0002-0394-6876
Yasuhiro ShimizuDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Akio YanagisawaDepartment of Pathology and Laboratory Medicine, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan.
Masafumi NakamuraDepartment of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kazuo HaraDepartment of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan.
Masayuki KitanoSecond Department of Internal Medicine, Wakayama Medical University School of Medicine, Wakayama, Japan.
Shinsuke KoshitaDepartment of Gastroenterology, Sendai City Medical Center, Sendai, Japan.
Tetsuya TakikawaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Toshifumi KinCenter for Gastroenterology, Teine-Keijinkai Hospital, Sapporo, Japan.
Mamoru TakenakaDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan.
Keiji HanadaDepartment of Gastroenterology, JA Onomichi General Hospital, Hiroshima, Japan.
Toshiharu UekiDepartment of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
Takao ItoiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Reiko YamadaDepartment of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan.
Takao OhtsukaDepartment of Digestive Surgery, Kagoshima University, Kagoshima, Japan.
Seiko HironoDivision of Hepato-Biliary-Pancreatic Surgery, Department of Gastroenterological Surgery, Hyogo Medical University, Nishinomiya, Japan.
Atsushi KannoDepartment of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan.
Yoshifumi TakeyamaDepartment of Surgery, Kindai University Faculty of Medicine, Osaka, Japan.
Atsushi MasamuneDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntraductal papillary mucinous neoplasms (IPMNs) are classified into three epithelial types with distinct biological behaviors. However, their effects on the postoperative outcomes remain unclear.

methodsThis multicenter retrospective study included 556 patients with IPMNs who underwent surgical resection. The epithelial types were categorized into the gastric (n = 323), intestinal (n = 160), and pancreatobiliary (n = 73) types. Their associations with the development of extrapancreatic lesions; remnant high-risk lesions (HRLs), including metachronous pancreatic ductal adenocarcinoma (PDAC); and disease-specific survival (DSS) were analyzed.

resultsFifty-one patients (9.2%) developed extrapancreatic lesions. The 10-year cumulative incidence rates for the gastric, intestinal, and pancreatobiliary types were 9.3%, 9.1%, and 32.0%, respectively (P < 0.001). Multivariate analysis identified invasive carcinoma, the gastric, and pancreatobiliary types as independent predictors. Among 516 patients who did not undergo total pancreatectomy, 40 (7.8%) and 13 (2.5%) developed HRLs and metachronous PDAC, respectively. The 10-year cumulative incidence rates of HRLs and metachronous PDAC for the gastric, intestinal, and pancreatobiliary types were 7.0%, 16.2%, and 37.2% and 1.8%, 3.7%, and 22.7%, respectively (P = 0.001 and P = 0.012). In multivariate analysis, the pancreatobiliary type was an independent predictor of metachronous PDAC. Five-year DSS rates for the gastric, intestinal, and pancreatobiliary types were 92.5%, 96.0%, and 76.1% (P < 0.001), respectively. Multivariate analysis identified invasive carcinoma, the gastric, and pancreatobiliary types as independent prognostic factors for DSS.

conclusionsIPMN epithelial type can independently affect postoperative outcomes. In particular, the pancreatobiliary type has significant impact on the development of metachronous PDAC. Therefore, postoperative surveillance should be tailored according to the epithelial type.

Indexed as

Adenocarcinoma, MucinousCarcinoma, Pancreatic DuctalPancreatic Intraductal NeoplasmsPancreatic NeoplasmsAdultAgedAged, 80 and overFemaleHumansIncidenceMaleMiddle AgedNeoplasms, Second PrimaryPancreatectomyRetrospective StudiesTreatment OutcomeDisease-specific survivalEpithelial typeIntraductal papillary mucinous neoplasmMetachronous pancreatic ductal adenocarcinomaPancreatobiliary type

Identifiers

PMID39966119

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.