Evidence map›Paper›PMID 39966116›Full record

ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2025

The Impact of pre-operative aspirin administration on free flap survival rate in lower extremity reconstructio n.

Moath Zuhour, Bilsev İnce, Mahmut Tekecik, Majid Ismayilzade, Mehmet Dadacı

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Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. [Research progress on perioperative anticoagulants in perioperative period of free flap transplantation].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Moath ZuhourDepartment of Plastic, Reconstructive and Aesthetic Surgery, Private Hospital of Büyükşehir, Selçuklu, Konya, 42100, Turkey. muazzuhour@gmail.com.
Bilsev İnceDepartment of Plastic, Reconstructive and Aesthetic Surgery, Private clinic, İzmir, Türkiye, Turkey.
Mahmut TekecikDepartment of Plastic, Reconstructive and Aesthetic Surgery, Government hospital of Nevşehir, Nevşehir, Türkiye, Turkey.
Majid IsmayilzadeDepartment of Plastic, Reconstructive and Aesthetic Surgery, Istinye University, Istanbul, Türkiye, Turkey.
Mehmet DadacıDepartment of Plastic, Reconstructive and Aesthetic Surgery, Hospital of Meram Faculty of Medicine, University of Necmettin Erbakan, Konya, Türkiye, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTotal flap failure remains a reported complication, primarily due to arterial thrombosis. Although numerous studies have compared different intraoperative and postoperative anticoagulant regimens, none have specifically addressed the effectiveness of preoperative acetylsalicylic acid treatment. In this study, it was aimed to investigate the effect of pre-operative aspirin administration on free flap survival rate in lower extremity reconstruction. MATERIALS AND

methodsThis retrospective study included patients who underwent free flap transfers for lower extremity reconstruction. The patients were divided into two groups: those who received preoperative acetylsalicylic acid treatment and those who did not. The two groups were compared in terms of flap success and complication rates.

resultsA total of 117 patients were included. Of these, 42 patients received preoperative acetylsalicylic acid, while 75 did not. Trauma was the most common etiology, while burns were the least common. There was no statistically significant difference between the groups in terms of flap type or recipient artery (p > 0.05). Arterial thrombosis developed in 13 patients (11%), of whom only one had received preoperative acetylsalicylic acid. 7 of these patients experienced total flap loss. There was a statistically significant difference regarding total flap loss and arterial thrombosis (p < 0.05).

conclusionPreoperative acetylsalicylic acid treatment may improve free flap success rates by preventing arterial thrombosis. It was found to be effective in preventing arterial thrombosis when initiated in the preoperative period, before endothelial damage occurs during anastomosis. However, Clinicians should weigh the potential benefits of reduced thrombotic events against the risks of complications, such as hematomas, when considering preoperative aspirin administration.

Indexed as

AspirinFree Tissue FlapsGraft SurvivalLeg InjuriesLower ExtremityPlastic Surgery ProceduresThrombosisAdultAgedFemaleHumansMaleMiddle AgedPreoperative CareRetrospective StudiesAspirinAcetylsalicylic acidAnticoagulantAspirinFree flap failurePreoperativeThrombus

Identifiers

PMID39966116

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.