Evidence map›Paper›PMID 39966021›Full record

ArticleThe journal of prevention of Alzheimer's disease2025

Interactions of physical activity and lung function on cognitive health in older adults: Joint association and mediation analysis.

Peng Hu, Dan Song, Tian Heng, Ling-Ling Yang, Chuan-Chuan Bai, Rui He, Tao Liu, Ya-Xi Luo, Xiu-Qing Yao

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PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of prevention of Alzheimer's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peng HuDepartment of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Dan SongDepartment of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Tian HengDepartment of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ling-Ling YangDepartment of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chuan-Chuan BaiDepartment of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of Rehabilitation, University-Town Hospital of Chongqing Medical University, Chongqing, China.
Rui HeDepartment of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Tao LiuDepartment of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of Geriatrics, Chongqing Mental Health Centre, Chongqing, China.
Ya-Xi LuoDepartment of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: luoyaxi@hospital.cqmu.edu.cn.
Xiu-Qing YaoDepartment of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Municipality Clinical Research Center for Geriatric Medicine, Chongqing, China. Electronic address: dryaoxq@cqmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMaintaining cognitive health in old adults has become a significant public health challenge, with lung function and physical activity (PA) as essential modifiable factors. However, the joint and mediation effects of these two factors with cognition remain unclear.

objectivesThis study assesses the joint association and mediation effects of lung function and PA with cognition. DESIGN, SETTING, AND

participantsWe utilized cross-sectional data from the 2011-2012 U.S. National Health and Nutrition Examination Survey, including adults aged 60-79 assessed for lung function, PA, and cognition. MAIN OUTCOMES AND MEASURES: Lung function included forced expiratory volume in one second (FEV

resultsA total of 927 participants, representing 35,525,782 U.S. residents, were included, with a weighted median age of 65 (IQR, 63 -71) years, and 53.6 % were female. The results showed a significant positive association between lung function and cognitive function, with FEV

conclusionLung function and cognition may have a bidirectional relationship. The combination of active LTPA and better lung function was strongly associated with higher cognition, highlighting the need to strengthen exercise focused on lung function to maintain cognitive health in older adults.

Indexed as

CognitionExerciseLungAgedCross-Sectional StudiesFemaleForced Expiratory VolumeHumansMaleMediation AnalysisMiddle AgedNutrition SurveysRespiratory Function TestsUnited StatesVital CapacityCognitive functionLung functionMediation effectOlder adultsPhysical activity

Identifiers

PMID39966021
PMCPMC12183935

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.