Evidence map›Paper›PMID 39965927›Full record

ArticleRNA (New York, N.Y.)2025

A general RNA-templated RNA extension activity of

Drew Galls, Andreas U Mueller, Emily Greenwald, Andrew Z Fire

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Structural principles of transcriptional collisions.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Drew GallsDepartment of Genetics, Stanford University, Stanford, California 94305, USA dgalls@stanford.edu afire@stanford.edu.
Andreas U Mueller *Laboratory of Molecular Biophysics, The Rockefeller University, New York, New York 10065, USA.
Emily Greenwald *Department of Genetics, Stanford University, Stanford, California 94305, USA.
Andrew Z FireDepartment of Genetics, Stanford University, Stanford, California 94305, USA dgalls@stanford.edu afire@stanford.edu.

Funding

INSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2M
Structure, function, and regulation of the bacterial transcription cycleR35GM118130 · NIGMS · ROCKEFELLER UNIVERSITY · PI DARST, SETH A. · 2016 to 2025
$8.9M
Cellular Response to Genetic ChangeR35GM130366 · NIGMS · STANFORD UNIVERSITY · PI ANDREW Z. FIRE · 2019 to 2026
$4.8M
Mapping Molecular and Phenotypic Interactions in Alzheimers DiseaseR01AG066490 · NIA · STANFORD UNIVERSITY · PI MONTGOMERY, STEPHEN · 2020 to 2024
$3.6M
Identifying causal genetic variants and molecular mechanisms impacting mental healthR01MH125244 · NIMH · STANFORD UNIVERSITY · PI KUNDAJE, ANSHUL, MONTGOMERY, STEPHEN · 2021 to 2025
$3.0M
NHGRI NIH HHS T32 HG000044NIA NIH HHS R01 AG066490NIGMS NIH HHS R35 GM118130NIGMS NIH HHS R35 GM130366NIMH NIH HHS R01 MH125244
6 · The paper itself

Abstract

Multisubunit "DNA-dependent" RNA polymerases (RNAPs) have noncanonical RNA-directed RNA synthesis activity; this allows the synthesis of complementary RNA from RNA templates. Such noncanonical RNAP activities are biologically significant, serving RNA pathogens such as hepatitis delta virus (HDV) and contributing to cellular gene regulation. Despite the broad biological implications of these processes, our understanding of the underlying RNAP mechanisms remains incomplete. Using

Indexed as

DNA-Directed RNA PolymerasesEscherichia coliEscherichia coli ProteinsRNARNA, BacterialTemplates, GeneticTranscription, GeneticDNA-Directed RNA PolymerasesEscherichia coli ProteinsRNARNA, Bacterial6S RNAhepatitis delta virusRNA polymeraserolling hairpin replicationviroid

Identifiers

PMID39965927
PMCPMC12001968

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.