Evidence map›Paper›PMID 39965572›Full record

ArticleCell2025

HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity.

Skyler Y Blume, Ankur Garg, Yolanda Martí-Mateos, Ayush D Midha, Brandon T L Chew, Baiwei Lin, Cecile Yu, Ryan Dick, Patrick S Lee, Eva Situ and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Skyler Y BlumeGladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Ankur GargGladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Yolanda Martí-MateosGladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Ayush D MidhaGladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Brandon T L ChewGladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Baiwei LinMaze Therapeutics, 171 Oyster Point Blvd STE 300, South San Francisco, CA 94080, USA.
Cecile YuMaze Therapeutics, 171 Oyster Point Blvd STE 300, South San Francisco, CA 94080, USA.
Ryan DickMaze Therapeutics, 171 Oyster Point Blvd STE 300, South San Francisco, CA 94080, USA.
Patrick S LeeMaze Therapeutics, 171 Oyster Point Blvd STE 300, South San Francisco, CA 94080, USA.
Eva SituMaze Therapeutics, 171 Oyster Point Blvd STE 300, South San Francisco, CA 94080, USA.
Richa SarwaikarMaze Therapeutics, 171 Oyster Point Blvd STE 300, South San Francisco, CA 94080, USA.
Eric GreenMaze Therapeutics, 171 Oyster Point Blvd STE 300, South San Francisco, CA 94080, USA.
Vyas RamananMaze Therapeutics, 171 Oyster Point Blvd STE 300, South San Francisco, CA 94080, USA.
Gijsbert GrotenbregMaze Therapeutics, 171 Oyster Point Blvd STE 300, South San Francisco, CA 94080, USA.
Maarten HoekMaze Therapeutics, 171 Oyster Point Blvd STE 300, South San Francisco, CA 94080, USA.
Christopher SinzMaze Therapeutics, 171 Oyster Point Blvd STE 300, South San Francisco, CA 94080, USA.
Isha H JainGladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA; Arc Institute, 3181 Porter Dr, Palo Alto, CA 94304, USA. Electronic address: isha.jain@gladstone.ucsf.edu.

Funding

Medical Scientist Training Program (T32 NRSA Training Grant)T32GM141323 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aimee Kao · 2021 to 2026
$10.5M
Redesigning a Neuron's Breath: A Modern Twist to Classical Oxygen BiologyDP5OD026398 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAIN, ISHA HIMANI · 2018 to 2022
$2.2M
Investigating the role of BCAA metabolism in regulating adiposity during systemic hypoxia.F30DK139713 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Ayush Midha · 2024 to 2026
$138k
NIDDK NIH HHS F30 DK139713NIGMS NIH HHS T32 GM141323NIH HHS DP5 OD026398
6 · The paper itself

Abstract

We have previously demonstrated that chronic inhaled hypoxia is remarkably therapeutic in the premier animal model of mitochondrial Leigh syndrome, the Ndufs4 knockout (KO) mouse. Subsequent work has extended this finding to additional mitochondrial diseases and more common conditions. However, challenges inherent to gas-based therapies have hindered the rapid translation of our findings to the clinic. Here, we tested a small molecule (hereafter termed HypoxyStat) that increases the binding affinity of hemoglobin for oxygen, thereby decreasing oxygen offloading to tissues. Daily oral dosing of HypoxyStat caused systemic hypoxia in mice breathing normoxic (21% O

Indexed as

HemoglobinsHypoxiaLeigh DiseaseOxygenAnimalsDisease Models, AnimalElectron Transport Complex IHumansMiceMice, Inbred C57BLMice, KnockoutElectron Transport Complex IHemoglobinsNdufs4 protein, mouseOxygenhemoglobinhyperoxiahypoxiaLeigh syndromemitochondrial diseaseoxygenred blood cellstherapy

Identifiers

PMID39965572
PMCPMC12186697

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.