ArticleCell reports2025
Lung CD4
Abstract read
In one paragraph
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neutrophil-to-lymphocyte ratio as a biomarker for asthma identification and severity stratification: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Article
- Host-Pathogen Interactions Leading to Pneumonia Pathogenesis.Clinics in chest medicine · 2026Review
- Early-life viral infection generates pathological tissue-resident memory cells that contribute to asthma-like disease.JCI insight · 2026Article
- Inflammatory memory: the core mechanism driving allergic asthma recurrence and chronicity.Journal of thoracic disease · 2026Review
- Second-order regulation: IFN-γ suppresses IL-17A-mediated type 3 inflammation.Frontiers in immunology · 2026Article
- Exercise and tissue-resident memory T cells: from circulating numbers to spatial immune remodeling.Frontiers in immunology · 2026Review
- Early-life viral infections and asthma: new cells and ideas.Current opinion in pediatrics · 2025Review
- Neutrophil Heterogeneity in Airway Inflammatory Diseases.Inflammation · 2025Review
- Peptide ES15-1 derived from Haemonchus contortus promotes goat Th17 response by regulating the STAT3/RORγt pathway.Veterinary research · 2025Article
- The mysterious case of missing lymphocytes: a cautionary tale of interinstitutional variability in outcomes of lung dissociation protocols.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Perspectives on physics-based one-dimensional modeling of lung physiology.Frontiers in physiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Vijay Raaj RaviDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
Filiz T KorkmazPulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Carolina Lyon De AnaPulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Virology, Immunology, and Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Lu LuDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Feng-Zhi ShaoPulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Christine V OdomPulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Virology, Immunology, and Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Kimberly A BarkerPulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Virology, Immunology, and Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Aditya RamanujanPulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Emma N NiszczakDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
Wesley N GoltryPulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Ian M C MartinPulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Catherine T HaPulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Lee J QuintonPulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA; Department of Virology, Immunology, and Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Pathology and Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Matthew R JonesPulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Virology, Immunology, and Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Alan FinePulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Joshua D WelchDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA; Department of Computer Science and Engineering, University of Michigan, Ann Arbor, MI, USA.
Felicia ChenPulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Anna C BelkinaPulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Pathology and Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Flow Cytometry Core Facility, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Joseph P MizgerdPulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Virology, Immunology, and Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. Electronic address: jmizgerd@bu.edu.
Anukul T ShenoyDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA; Pulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: anukuls@umich.edu.
Funding
BIOLOGY OF THE LUNG--MULTIDISCIPLINARY PROGRAMT32HL007035 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton, JOSEPH P MIZGERD · 1985 to 2026
$24.3MPneumonia BiologyR35HL135756 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MIZGERD, JOSEPH P · 2017 to 2023
$6.6MQuantitative definition of cell identity from single-cell multi-omic, spatial, and perturbation dataR01HG010883 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joshua Welch · 2019 to 2026
$4.4MLung-resident antibacterial heterotypic immunityR01AI115053 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MIZGERD, JOSEPH P · 2015 to 2023
$4.0MThe Biology of LIF During PneumoniaR01HL111449 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI QUINTON, LEE · 2012 to 2020
$3.7MLOX-1 as a protective countermeasure in response to lung infectionR01HL165718 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Lee Quinton · 2023 to 2026
$3.0MThe B cell repertoire as a window into the nature and impact of the lung viromeR33HL137081 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FEARNS, RACHEL, KEPLER, THOMAS B · 2019 to 2021
$2.4MFibrin in the Infected LungR01HL171499 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JOSEPH P MIZGERD · 2024 to 2026
$2.3MOrigins and functional roles of Miwi2-positive multiciliated cells during inflammationR01HL136725 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FINE, ALAN FINE, JONES, MATTHEW ROBERT · 2018 to 2021
$1.6MLiver-derived protection during pneumonia and sepsisR01GM120060 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI QUINTON, LEE · 2017 to 2020
$1.3MLung epithelial cell reprogramming by CD4 T cellsR00HL157555 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHENOY, ANUKUL T · 2023 to 2025
$747kLung epithelial cell reprogramming by CD4 T cellsK99HL157555 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SHENOY, ANUKUL T · 2022 to 2023
$271kNHGRI NIH HHS R01 HG010883NHLBI NIH HHS F31 HL142199NHLBI NIH HHS F32 HL147461NHLBI NIH HHS K99 HL157555NHLBI NIH HHS K99 HL159258NHLBI NIH HHS R00 HL157555NHLBI NIH HHS R01 HL111449NHLBI NIH HHS R01 HL136725NHLBI NIH HHS R01 HL165718NHLBI NIH HHS R01 HL171499NHLBI NIH HHS R33 HL137081NHLBI NIH HHS R35 HL135756NHLBI NIH HHS T32 HL007035NIAID NIH HHS R01 AI115053NIGMS NIH HHS R01 GM120060
Abstract
Neutrophilic asthma is a vexing disease, but mechanistic and therapeutic advancements will require better models of allergy-induced airway neutrophilia. Here, we find that periodic ovalbumin (OVA) inhalation in sensitized mice elicits rapid allergic airway inflammation and pathophysiology mimicking neutrophilic asthma. OVA-experienced murine lungs harbor diverse clusters of CD4
Indexed as
AsthmaCD4-Positive T-LymphocytesHypersensitivityImmunologic MemoryLungMemory T CellsNeutrophilsAnimalsChemokine CXCL5FemaleHumansInterferon-gammaInterleukin-17MiceMice, Inbred C57BLMucin 5ACChemokine CXCL5Interferon-gammaInterleukin-17Mucin 5ACOvalbuminallergyantigen presentationCD4(+) T cellsCP: Immunologyepithelial cellsIFN-γMHC class IImucosal immunityneutrophilic asthmaT(H)17 cellstissue-resident memory T(RM) cells
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.