Evidence map›Paper›PMID 39965116›Full record

ReviewEndocrine reviews2025

Subtyping of Primary Aldosteronism by Adrenal Venous Sampling.

Gian Paolo Rossi, Michele Battistel, Teresa Maria Seccia, Federico Bernardo Rossi, Giacomo Rossitto

Abstract readReview
In one paragraph

Review in Endocrine reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Observational
  5. Primary aldosteronism.Nature reviews. Disease primers · 2026
    Review
  6. The value of targeting CXCR4 withEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  7. Effect of collection timing on selectivity index in unstimulated adrenal venous sampling: discovery and validation.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  8. Mineralocorticoid Receptor Antagonist Pre-Adrenalectomy in Primary Aldosteronism.The Journal of clinical endocrinology and metabolism · 2026
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gian Paolo RossiInternal Emergency Medicine and Specialized Hypertension Center, Department of Medicine DIMED, University Hospital, University of Padua, 35128 Padova, Italy.ORCID 0000-0002-7963-0931
Michele BattistelInstitute of Radiology, Department of Medicine DIMED, University Hospital, University of Padua, 35128 Padova, Italy.ORCID 0000-0003-1535-4437
Teresa Maria SecciaInternal Emergency Medicine and Specialized Hypertension Center, Department of Medicine DIMED, University Hospital, University of Padua, 35128 Padova, Italy.ORCID 0000-0002-3639-4086
Federico Bernardo RossiJoint International PhD Program in Arterial Hypertension and Vascular Biology (ARHYVAB), University of Padua and Sapienza University, 35128 Padova, Italy.ORCID 0009-0002-7533-4577
Giacomo RossittoInternal Emergency Medicine and Specialized Hypertension Center, Department of Medicine DIMED, University Hospital, University of Padua, 35128 Padova, Italy.ORCID 0000-0001-9023-0835

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary aldosteronism (PA), the most common cause of arterial hypertension, is surgically curable if a unilateral source of the hyperaldosteronism is discovered. To identify which patients are curable, all current guidelines recommend adrenal venous sampling (AVS), a procedure which, albeit simple in principle, remains scarcely available and markedly underutilized, because it is still perceived as technically challenging, invasive, and difficult to interpret. The lack of uniformly accepted standards for performance and interpretation of AVS, alongside the diffuse concerns that (although quite rarely) it can be complicated by adrenal vein rupture, contribute to the scant utilization of AVS. In the last decade, several major studies have led to a greater understanding of the use of AVS in PA patients, thus paving the way to a more rational and effective application that can enable diagnosis of many more PA patients with a unilateral form of the disease to be referred for curative adrenalectomy. Moreover, microcatheters and androstenedione have been introduced to increase the success rate. This review provides updated information on the subtyping of PA by means of AVS and examines key issues on the selection and preparation of patients, the optimal performance of the procedure, and the interpretation of its results for diagnostic purposes, even in the most challenging cases. Situations when AVS can be omitted before surgery and alternative functional imaging techniques that have been proposed to identify unilateral surgical curable PA to circumvent the bottleneck represented by the limited availability of AVS worldwide, are also discussed.

Indexed as

Adrenal GlandsHyperaldosteronismAldosteroneBlood Specimen CollectionHumansVeinsAldosteroneadrenal vein samplingaldosteronediagnosisendocrine hypertensionhyperaldosteronism subtypesprimary aldosteronism

Identifiers

PMID39965116
PMCPMC12259235

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.