Evidence map›Paper›PMID 39964720›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Stepwise activation of SARM1 for cell death and axon degeneration revealed by a biosynthetic NMN mimic.

Yinpin Huang, Jun Zhang, Wenbin Zhang, Jie Chen, Sijia Chen, Qincui Wu, Sanduo Zheng, Xiaodong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Direct activation of SARM1 by dsDNA is not supported by biochemical and cellular evidence.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. A metabolic cell death program downstream of SARM1 couples NADProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yinpin Huang *Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 10094, China.
Jun Zhang *Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 10094, China.ORCID 0000-0001-5521-2092
Wenbin Zhang *Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 10094, China.
Jie ChenNational Institute of Biological Sciences, Beijing 102206, China.
Sijia ChenTsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 10094, China.
Qincui WuNational Institute of Biological Sciences, Beijing 102206, China.
Sanduo ZhengTsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 10094, China.ORCID 0000-0002-7784-0177
Xiaodong WangTsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 10094, China.ORCID 0000-0001-9885-356X

Funding

Beijing Education Committee Cooperation Building Foundation Project InstitutionalMinistry of Science and Technology of China institutional
6 · The paper itself

Abstract

Axon degeneration, driven by the NAD

Indexed as

Armadillo Domain ProteinsAxonsCytoskeletal ProteinsNerve DegenerationNicotinamide MononucleotideAnimalsCell DeathCryoelectron MicroscopyHumansMiceNADNicotinamide PhosphoribosyltransferaseArmadillo Domain ProteinsCytoskeletal ProteinsNADNicotinamide MononucleotideNicotinamide PhosphoribosyltransferaseSARM1 protein, humanSARM1 protein, mouseaxon degenerationNADSARM1

Identifiers

PMID39964720
PMCPMC11874154

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.