ArticleMolecular biology reports2025
Low-intensity pulsed ultrasound promotes proliferation and differentiation of neural stem cells to enhance spinal cord injury recovery.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Therapeutic potential of ultrasound for spinal cord injury.Neural regeneration research · 2026Article
- Overcoming Barriers to Axonal Regeneration in Spinal Cord Injury: Mechanistic Insights and Therapeutic Frontiers.CNS neuroscience & therapeutics · 2026Review
- Low-Intensity Pulsed Ultrasound in Peripheral and Central Nerve Repair: Mechanisms and Emerging Therapeutic Strategies.Journal of functional biomaterials · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundNeural stem cells (NSCs) are known for their high capacity for proliferation, self-renewal, and multidirectional differentiation. However, they often fail to survive or differentiate into mature neurons capable of replacing lost neurons. This study evaluated the potential role of low-intensity pulsed ultrasound (LIPUS) in promoting NSC proliferation and differentiation both in vitro and in vivo, as well as its role in enhancing spinal cord injury (SCI) recovery.
methodsNSCs were isolated, stimulated with LIPUS, and characterized through identification and detection assays. The safety and efficacy of LIPUS in promoting NSC proliferation and differentiation were assessed through cell viability and apoptosis assays, and neuronal marker expression analysis. In vivo, NSCs encoding fluorescent proteins were transplanted into a rat model of SCI. The SCI rats received LIPUS for 4 weeks. Later, functional recovery, morphological changes and neuronal structures were evaluated.
resultThe isolated NSCs were successfully identified. LIPUS significantly enhanced NSC proliferation and increased the expression of key neurogenic markers and neurotrophic factors, while reducing GFAP expression and avoiding apoptosis. In vivo, the NSCs/LIPUS + group demonstrated higher survival and differentiation of transplanted NSCs, along with improved BBB scores and enhanced neural marker expression compared with the NSCs/LIPUS - group.
conclusionLIPUS stimulation effectively promoted NSC proliferation and differentiation and enhanced the survival and function of transplanted NSCs at the SCI site, leading to improved SCI recovery.
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Registered trials
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