Evidence map›Paper›PMID 39964534›Full record

ArticleEuropean journal of nutrition2025

Refined highland barley ameliorates obesity-associated insulin resistance in high-fat diet-fed mice by targeting the gut microbiota and liver transcriptomics.

Tong Wu, Zijian Dai, Yingting Luo, Qinye Yu, Yiyun Zhang, Xin Bao, Rong Li, Yuhong Zhang, Jing Hao, Qun Shen and 1 more

Abstract read
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In one paragraph

Article in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tong WuCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Zijian DaiCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Yingting LuoCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Qinye YuCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Yiyun ZhangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Xin BaoCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Rong LiCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Yuhong ZhangTibet Academy of Agriculture and Animal Sciences, Lhasa, 850002, China.
Jing HaoQinghai Tianyoude Technology Investment Management Group Co., Ltd, Qinghai, 810500, China.
Qun ShenCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Yong XueCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China. xueyong@cau.edu.cn.

Funding

Research Team Project of Natural Science Foundation of Heilongjiang Province TD2020C003the National Key Research and Development Project 2018YFE0206300-02the study of highland barley powder and compound powder on quality improvement, storage stability and industrial application 2021-Y-11
6 · The paper itself

Abstract

purposeIt is generally believed that refined grains lack nutritional value compared to whole grains. The objective of this study was to investigate whether refined highland barley (RHB) holds the potential to combat obesity-associated insulin resistance.

methodsThirty-two male 6-week-old C57BL/6J mice were randomly divided into four groups fed with a normal chow diet, a high-fat diet (HFD), a 30% RHB supplemented HFD diet, and a 30% whole-grain highland barley (WGHB) supplemented HFD diet. We examined the anti-obesity and anti-insulin resistance effects of RHB and compared them with WGHB in mice.

resultsRHB intervention effectively improved obesity and insulin resistance, enhanced the intestinal mucosal barrier, and reduced inflammation. Moreover, it promoted the abundance of beneficial gut bacteria such as Akkermansia, Bifidobacterium, Lachnospiraceae_NK4A136_group, Lachnospiraceae_UCG-001, Alloprevotella, and increased the production of short-chain fatty acids (SCFAs) in faeces. Additionally, RHB intervention modulated liver gene transcription, downregulating inflammatory genes like IRF3/7, STAT1/2, NLRP3, and TLR2.

conclusionsRHB could effectively alleviate obesity-related insulin resistance by targeting gut microbiota and liver transcriptomics, and its beneficial impacts are comparable to those of WGHB.

Indexed as

Diet, High-FatGastrointestinal MicrobiomeHordeumInsulin ResistanceLiverObesityTranscriptomeAnimalsMaleMiceMice, Inbred C57BLGut microbiotaHypoglycemic effectInflammationLiver transcriptomeRefined highland barley

Identifiers

PMID39964534

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.