ReviewProbiotics and antimicrobial proteins2026
Gut Microbiota and Postbiotic Metabolites: Biotic Intervention for Enhancing Vaccine Responses and Personalized Medicine for Disease Prevention.
Review in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Immunosenescence and Vaccine Efficacy in Aging: Dynamic Interplay of Gut Microbiota and mTOR Signaling Pathways.Aging cell · 2026Review
- Metabolic dysregulation reshapes the immune landscape: The gut microbiota-mTOR axis in respiratory viral infection immunity.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Review
- Harnessing the gut microbiome to combat tuberculosis: a technological and clinical review.Frontiers in cellular and infection microbiology · 2026Review
- Umbilical Cord Mesenchymal Stem Cells as a Meritorious Option to Treat Psoriasis.Current stem cell research & therapy · 2026Review
- Exploring the Therapeutic Role of Pregnane X Receptor Activation in Acute Kidney Injury: Mechanisms and Clinical Implications.Current molecular medicine · 2026Review
- Harnessing PANoptosis for Innate Immune Response.Current pharmaceutical design · 2026Article
- Single-Cell Transcriptome and Microbiome Profiling Uncover Ileal Immune Impairment in Intrauterine Growth-Retarded Piglets.Current pharmaceutical design · 2026Article
- Gut microbiota as a regulator of vaccine efficacy: implications for personalized vaccination.Gut microbes · 2025Review
- Article
- Advances in ovarian cancer: biological insights, therapeutic innovations, and future perspectives.Journal of ovarian research · 2025Review
- Murine model of antibiotic-associated Staphylococcus aureus gastrointestinal infections (SAGII) and colonization.Gut pathogens · 2025Article
- The Microecological-Immune Axis in Pediatric Allergic Diseases: Imbalance Mechanisms and Regulatory Interventions.Nutrients · 2025Review
- Gut microbiome in gastrointestinal neoplasms: from mechanisms to precision therapeutic strategies.Gut pathogens · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The creation of vaccines has revolutionized several aspects of the game in the fight against transmissible diseases, protecting countless individuals around the globe. Several vaccines against potentially fatal diseases such as diphtheria, pertussis, polio, measles, tetanus, influenza, and smallpox have significantly reduced disease risks and successfully immunized individuals against these serious health threats. The immune response generated by vaccination plays a crucial role in mitigating disease risks by stimulating the production of specific antibodies targeting the relevant pathogens. However, the efficacy of vaccines can vary among communities and people due to several factors, including heredity, age, sex, and preexisting health conditions. The multitude of microbes that call the human digestive tract the microbiota have a pivotal role in regulating immunological reactions to immunization, according to mounting data from both experimental models and research trials. Nutritional supplementation with beneficial microbes, such as probiotic bacteria, has been shown to have immune-related benefits, including enhancements of immune system responses, and has the potential to modify the variety that makes up the microbiota. The effectiveness of vaccines can be enhanced by using probiotics, which work by fostering a balanced gut microbiome. New research reveals that the immune response can be influenced by both live and dormant probiotic bacteria, as well as postbiotics, which are byproducts of the metabolism of probiotics. These substances have immunomodulatory functions and are essential in regulating how the immune system reacts to vaccines. This review aims to summarize the available research, explore the possible immune system functions that could explain these effects, and ultimately speculate about how postbiotics, aimed at the biotic microbiota, could improve the efficacy of vaccines. The review further addresses postbiotics' challenges, regulatory aspects, and future directives for biotherapeutic products that could enhance vaccine efficacy and be tailored for personalized treatments.
Indexed as
Identifiers
39964413What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.