Evidence map›Paper›PMID 39964201›Full record

ArticleACS applied bio materials2025

Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefits.

Cosimo Ligorio, Elham Tavasoli, Nevena Karaman-Jurukovska, Abraham Ittycheri, Anna M Kotowska, Mohammed H Khan, David J Scurr, Shovit A Gupta, Leah V Moogan, Jaime Emmetsberger and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Cosimo LigorioBiodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, United Kingdom.ORCID 0000-0001-5917-4652
Elham TavasoliAdvanced Technology Pioneering, The Estée Lauder Companies, Melville, New York 11747-3115, United States.
Nevena Karaman-JurukovskaAdvanced Technology Pioneering, The Estée Lauder Companies, Melville, New York 11747-3115, United States.
Abraham IttycheriDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York 13902-4400, United States.
Anna M KotowskaSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
Mohammed H KhanSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
David J ScurrSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, United Kingdom.ORCID 0000-0003-0859-3886
Shovit A GuptaDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York 13902-4400, United States.
Leah V MooganDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York 13902-4400, United States.
Jaime EmmetsbergerAdvanced Technology Pioneering, The Estée Lauder Companies, Melville, New York 11747-3115, United States.
Fake LuDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York 13902-4400, United States.ORCID 0000-0001-6281-7639
Guy K GermanDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York 13902-4400, United States.ORCID 0000-0003-2872-4775
Tom MammoneAdvanced Technology Pioneering, The Estée Lauder Companies, Melville, New York 11747-3115, United States.
Alvaro MataBiodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, United Kingdom.ORCID 0000-0002-6739-9111

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Self-assembling peptides (SAPs) represent a rich source of building blocks that interact with biological structures. For instance, cosmetic SAPs like Palmitoyl hexapeptide-12 have gained increasing interest for their anti-aging properties. However, their short-term impact on the skin composition and mechanics remains unclear. In this study, a battery of label-free techniques is exploited to objectively monitor the effects of Palmitoyl hexapeptide-12 on human skin. Orbital trapping secondary ion mass spectrometry (OrbiSIMS) is used to discern between Palmitoyl hexapeptide-12 sol and gel forms, tracking its self-assembly and penetration within full-thickness human skin. Palmitoyl hexapeptide-12 is shown to permeate both stratum corneum and epidermal layers, initiating gel formation by harnessing endogenous ions. Hence, the ability of the peptide to strengthen and repair the skin barrier after delipidation is also demonstrated through a high-throughput mechanical characterization and stimulated Raman scattering (SRS). Finally, the co-assembling properties of Palmitoyl hexapeptide-12 with native skin molecules are shown via

Indexed as

Biocompatible MaterialsOligopeptidesSkinHumansMaterials TestingParticle SizeSkin CareBiocompatible MaterialsOligopeptidescosmeticshuman skinOrbiSIMSPalmitoyl hexapeptide-12self-assembling peptidesSRS

Identifiers

PMID39964201
PMCPMC11920943

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.