Evidence map›Paper›PMID 39964163›Full record

ArticlemBio2025

Gene regulatory network resource aids in predicting trans-acting regulators of biosynthetic gene clusters in

Hye-Won Seo, Jin Woo Bok, Nancy P Keller

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hye-Won SeoDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-2734-7050
Jin Woo BokDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Nancy P KellerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-4386-9473

Funding

V. cholerae iron transport mechanisms and pathogenesisR01AI050669 · NIAID · UNIVERSITY OF TEXAS AUSTIN · PI PAYNE, SHELLEY M. · 2002 to 2006
$1.5M
HHS | National Institutes of Health (NIH) R01 AI50669NIAID NIH HHS R01 AI050669
6 · The paper itself

Abstract

The field of secondary metabolism has greatly benefitted from computational advances in recent years. This has been particularly true for fungal natural product studies. Strides in genome mining have led to the identification of an extraordinary number of secondary metabolite biosynthetic gene clusters (BGCs) across the fungal Kingdom and metabologenomic platforms can group BGCs into gene cluster families and link them to initial chemical structures. Missing are computational applications focused on identifying BGC regulatory networks. Here, we applied the new online gene regulatory network resource, GRAsp (

Indexed as

Aspergillus fumigatusBiosynthetic PathwaysComputational BiologyGene Expression Regulation, FungalGene Regulatory NetworksMultigene FamilyFungal ProteinsGliotoxinSecondary MetabolismTranscription FactorsFungal ProteinsGliotoxinTranscription FactorsAspergillus fumigatusbiosynthetic gene clusterglobal regulatory networkssecondary metabolismtrans-acting regulator

Identifiers

PMID39964163
PMCPMC11898546

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.