Evidence map›Paper›PMID 39964042›Full record

ArticlePest management science2025

Evaluation of GS-omega/kappa-Hxtx-Hv1a and Bt toxins against Bt-resistant and -susceptible strains of Helicoverpa zea (Boddie) and Spodoptera frugiperda (J.E. Smith).

Simeon Ross, Fei Yang, José C Santiago-González, Heba Abdelgaffar, Dawson D Kerns, Juan Luis Jurat-Fuentes, Xiaocun Sun, Dayna Collett, David L Kerns

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pest management science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Toxicity of NanoemulsifiedPlants (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Simeon RossDepartment of Entomology, Texas A&M University, College Station, TX, USA.
Fei YangDepartment of Entomology, University of Minnesota, St Paul, MN, USA.
José C Santiago-GonzálezDepartment of Entomology, Texas A&M AgriLife Research and Extension at Amarillo, Amarillo, USA.
Heba AbdelgaffarDepartment of Entomology and Plant Pathology, University of Tennessee, Knoxville, TN, USA.
Dawson D KernsDepartment of Entomology and Plant Pathology, University of Tennessee, Knoxville, TN, USA.
Juan Luis Jurat-FuentesDepartment of Entomology and Plant Pathology, University of Tennessee, Knoxville, TN, USA.ORCID https://orcid.org/0000-0002-8945-1814
Xiaocun SunResearch Computing Support, Office of Information Technology, University of Tennessee, Knoxville, TN, USA.
Dayna CollettVestaron Crop Protection, Research Triangle Park, NC, USA.
David L KernsDepartment of Entomology, Texas A&M University, College Station, TX, USA.

Funding

National Institute of Food and Agriculture
6 · The paper itself

Abstract

backgroundHelicoverpa zea and Spodoptera frugiperda are destructive insect pests of cotton and corn. Both have evolved practical resistance to transgenic crops producing Bacillus thuringiensis (Bt) toxins in the United States. GS-omega/kappa-Hxtx-Hv1a (ω/κ-Hv1a) is a novel biopesticide derived from spider venom with activity against lepidopteran pests. The efficacy of ω/κ-Hv1a is dependent on combining it with a facilitator product such as a Bt-based insecticide. However, it is unknown if ω/κ-Hv1a can be an alternative for the management of Bt resistance. In this study, we tested the effect of ω/κ-Hv1a alone or in the presence of Bt toxins against susceptible and resistant H. zea and S. frugiperda.

resultsDiet overlays with 5 μg cm

conclusionThe study confirms that ω/κ-Hv1a activity against H. zea is significantly enhanced by a facilitator mechanism. Our results suggest Cry1Ac pore formation in the midgut membrane of Cry-resistant H. zea, enables the activity of ω/κ-Hv1a. Vip3Aa resistance in H. zea involves altered toxin-binding, consequently preventing pore formation and activity of ω/κ-Hv1a. Therefore, insecticides containing ω/κ-Hv1a may be an alternative for managing Cry-resistant H. zea in cotton and help delay the evolution of insect resistance. © 2025 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Indexed as

Bacterial ProteinsBacterial ToxinsEndotoxinsInsecticide ResistanceInsecticidesMothsSpider VenomsSpodopteraAnimalsBacillus thuringiensisBacillus thuringiensis ToxinsLarvaPest Control, BiologicalBacillus thuringiensis ToxinsBacterial ProteinsBacterial ToxinsEndotoxinsInsecticidesSpider VenomsVip3A protein, Bacillus thuringiensisBacillus thuringiensisBt cornHelicoverpa zearesistanceSpodoptera frugiperdaω/κ‐Hv1a

Identifiers

PMID39964042
PMCPMC12159400

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.