Evidence map›Paper›PMID 39963956›Full record

Trial reportGut microbes2025

Gut microbiome changes with micronutrient supplementation in children with attention-deficit/hyperactivity disorder: the MADDY study.

Hayleigh K Ast, Matthew Hammer, Shiqi Zhang, Alisha Bruton, Irene E Hatsu, Brenda Leung, Ryan McClure, Priya Srikanth, Yuliya Farris, Lydia Norby-Adams and 6 more

Abstract readClinical Trial, Phase IClinical Trial, Phase IIMulticenter Study
In one paragraph

Trial report in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hayleigh K AstDepartment of Psychiatry, Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0002-2521-0309
Matthew HammerDepartment of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0001-7155-4359
Shiqi ZhangDepartment of Human Sciences, The Ohio State University, Columbus, OH, USA.
Alisha BrutonDepartment of Psychiatry, Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0002-5929-3149
Irene E HatsuDepartment of Human Sciences, The Ohio State University, Columbus, OH, USA.ORCID 0000-0003-0501-9088
Brenda LeungFaculty of Health Sciences, University of Lethbridge, Lethbridge, AB, Canada.ORCID 0000-0002-8871-3210
Ryan McClurePacific Northwest National Laboratory, Richland, WA, USA.ORCID 0000-0003-0573-6917
Priya SrikanthOregon Health and Science University-Portland State University School of Public Health, Portland, OR, USA.ORCID 0000-0002-0906-6757
Yuliya FarrisPacific Northwest National Laboratory, Richland, WA, USA.
Lydia Norby-AdamsDepartment of Psychiatry, Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, USA.ORCID 0009-0001-1248-8723
Lisa M RobinetteDepartment of Human Sciences, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-9314-9538
L Eugene ArnoldDepartment of Psychiatry & Behavioral Health, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-0886-0692
Jonathan R SwannSchool of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID 0000-0002-6485-4529
Jiangjiang ZhuDepartment of Human Sciences, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-4548-8949
Lisa KarstensDepartment of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0001-6188-4397
Jeanette M JohnstoneDepartment of Psychiatry, Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0002-5041-1524

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUL1TR002733 · NCATS · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$28.9M
Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
The Ohio State University Center for Clinical and Translational Science (UL1)UL1TR000090 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2012 to 2013
$7.9M
CAM Research Training in Neuroscience &StressT32AT002688 · NCCIH · OREGON HEALTH & SCIENCE UNIVERSITY · PI OKEN, BARRY S, SOUMYANATH, AMALA · 2005 to 2025
$7.2M
Optimizing Research Methodology in a Multinutrient Study of Racially and Ethnically Diverse Children with ADHD and Emotional DysregulationK23AT012068 · NCCIH · OREGON HEALTH & SCIENCE UNIVERSITY · PI JOHNSTONE, JEANETTE M · 2022 to 2025
$700k
NCATS NIH HHS UL1 TR000090NCATS NIH HHS UL1 TR000128NCATS NIH HHS UL1 TR002369NCATS NIH HHS UL1 TR002733NCCIH NIH HHS 5R90AT00892403NCCIH NIH HHS K23 AT012068NCCIH NIH HHS T32 AT002688
6 · The paper itself

Abstract

Micronutrients have demonstrated promise in managing inattention and emotional dysregulation in children with attention-deficit/hyperactivity disorder (ADHD). One plausible pathway by which micronutrients improve symptoms is the gut microbiome. This study examines changes in fecal microbial composition and diversity after micronutrient supplementation in children with ADHD (

Indexed as

Attention Deficit Disorder with HyperactivityBacteriaDietary SupplementsGastrointestinal MicrobiomeMicronutrientsAdolescentChildDouble-Blind MethodFecesFemaleHumansMaleRNA, Ribosomal, 16SMicronutrientsRNA, Ribosomal, 16SADHDchildrenmicrobiomemicronutrients

Identifiers

PMID39963956
PMCPMC11845018

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.