ArticleThe Journal of infectious diseases2025
Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated With Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children With Severe Malaria.
Ruth Namazzi, Caroline Kazinga, Giselle Lima-Cooper, Claire Liepmann, Michael J Goings, Olivia Bednarski, Marco Abreu, Tae-Hwi Schwantes-An, Anthony Batte, Robert O Opoka and 2 more
Abstract read
In one paragraphArticle in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Ruth NamazziDepartment of Pediatrics, Makerere University College of Health Sciences, Kampala, Uganda.ORCID 0000-0003-2459-6526 Caroline KazingaGlobal Health Uganda, Kampala, Uganda.
Giselle Lima-CooperRyan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0001-5168-9125 Claire LiepmannRyan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Michael J GoingsRyan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Olivia BednarskiRyan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0003-3029-8461 Marco AbreuDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Tae-Hwi Schwantes-AnDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0001-6387-0095 Anthony BatteDepartment of Pediatrics, Makerere University College of Health Sciences, Kampala, Uganda.ORCID 0000-0001-7463-5277 Robert O OpokaGlobal Health Uganda, Kampala, Uganda.
Chandy C JohnRyan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-1634-1411 Funding
Severe Malaria And Risk to The Brain (SMART Brain)R01NS055349 · NINDS · UNIVERSITY OF MINNESOTA · PI Chandy C. John, Ruth Namazzi · 2008 to 2026
$11.2MMalaria associated pathogenesis of chronic kidney disease (MAP-CKD)R01AI165946 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI Andrea L. Conroy · 2022 to 2026
$3.2MNRSA Training CoreTL1TR002531 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI FOTI, DANIEL JUSTIN, HURLEY, THOMAS D. · 2018 to 2022
$2.5MResearch training in infection, nutrition and neurodevelopment in UgandaD43TW010928 · FIC · INDIANA UNIVERSITY INDIANAPOLIS · PI Chandy C. John · 2018 to 2026
$1.9MIndiana University Kidney Training Program (IU-KTP)T32DK120524 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M · 2019 to 2023
$1.3MMechanisms of acute kidney injury in malaria - Resubmission - 1R21AI151349 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RODRIGUEZ, ANA · 2021 to 2022
$476kFIC NIH HHS D43 TW010928National Institute of Allergy and Infectious Diseases R01AI165946National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke R01NS055349NCATS NIH HHS TL1 TR002531NCATS NIH HHS TL1TR002531NIAID NIH HHS R01 AI165946NIAID NIH HHS R21 AI151349NIDDK NIH HHS 5T32DK120524-05NIDDK NIH HHS T32 DK120524NIHNINDS NIH HHS R01 NS055349Ralph W. and Grace M. Showalter
6 · The paper itselfAbstract
Acute kidney injury (AKI) is common and predicts mortality in severe malaria. Studies have reported an increased incidence of AKI in males with hemolytic features of severe malaria. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked enzymopathy, can induce hemolysis. We evaluated whether the G6PD African allele (A-) was associated with AKI in children with severe malaria. The prevalence of G6PD deficiency was 16.7% among hemizygous male children and 2.4% in female children. G6PD deficiency was associated with 2.56-fold odds of AKI (95% confidence interval, 1.33-4.93; P = .005), adjusting for age, sex, site, nutritional status, and features of hemolysis.
Indexed as
Acute Kidney InjuryGlucosephosphate Dehydrogenase DeficiencyMalariaChildChild, PreschoolFemaleGlucosephosphate DehydrogenaseHemolysisHumansInfantMalePrevalenceRisk FactorsGlucosephosphate DehydrogenaseAKIG6PDintravascular hemolysisSevere malariasex differences
Identifiers
PMID39963714
PMCPMC12308644
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