ReviewOpen forum infectious diseases2025
Leptospirosis-Improving Healthcare Outcomes for a Neglected Tropical Disease.
Review in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy and safety outcomes reported in human leptospirosis studies to inform the development of a core outcome and core outcome measurement set: A systematic review.PLoS neglected tropical diseases · 2026Pooled it
- Human-to-human transmission of leptospirosis: a global systematic review.Frontiers in public health · 2026Pooled it
- β-Lactam antibiotics trigger mouse TLR2/4- and human TLR2/5-dependent Jarisch-Herxheimer reaction in leptospirosis.bioRxiv : the preprint server for biology · 2026Article
- Multidrug-resistant and virulence traits in genetically distinct vesicular Leptospira inhabiting farmland and sewage in Southern India.Scientific reports · 2026Article
- A Leptospirosis Outbreak in a Riding Stable in Central Italy.Veterinary sciences · 2026Article
- Clinical Predictors of Fatal Outcomes from Human Leptospirosis, Thailand, 2015-2024.Emerging infectious diseases · 2026Observational
- Leptospirosis presenting with fever, jaundice, and generalized lymphadenopathy: a case report with diagnostic challenges.Annals of medicine and surgery (2012) · 2026Article
- Zoonotic transmission risk in flood-prone river basins: community knowledge and behavioral determinants of leptospirosis in eastern Ethiopia.BMC public health · 2026Article
- Leptospira interrogans HtrA protease is a potent inducer of multifaceted cellular responses.Antonie van Leeuwenhoek · 2026Article
- Concurrent Scrub Typhus, Dengue, and Leptospirosis: A Rare Triple Co-Infection: A Case Report and Comprehensive Literature Review.Clinical case reports · 2026Article
- Early diagnosis and treatment of leptospirosis: Optimizing clinical outcomes.The Journal of infection · 2026Review
- Leptospirosis in Central Romania: A 17-Year Single-Center Cohort Study of Hospitalized Adults.Microorganisms · 2026Article
- Leptospirosis in Southeast Asia: Investigating Seroprevalence, Transmission Patterns, and Diagnostic Challenges.Tropical medicine and infectious disease · 2026Review
- Spatiotemporal dynamics and environmental trends of reported human leptospirosis in Sri Lanka, 2007-2024.Frontiers in public health · 2026Article
- Neuroimmune cross-talk inFrontiers in immunology · 2026Review
- [Floods in Rio Grande do Sul State, Brazil, in 2024 and their effects on the epidemiology of leptospirosis].Cadernos de saude publica · 2026Article
- Case Report: Isolated diffuse alveolar hemorrhage as the sole severe manifestation of atypical leptospirosis without jaundice or acute kidney injury and the diagnostic value of BALF metagenomic next-generation sequencing.Frontiers in medicine · 2026Article
- Occupation as an associated risk factor for leptospirosis.Frontiers in public health · 2026Article
- Review
- The Characteristics of Patients That Develop Severe Leptospirosis: A Scoping Review.Pathogens (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Leptospirosis is a globally distributed zoonotic disease transmitted from animal reservoirs to humans. It is particularly common in tropical regions of Africa, Asia, and Central and South America during heavy rainfall when bacterial spirochetes are released from soil into areas of flooding. Despite causing >1 million severe cases, 58 900 deaths, and 2.9 million disability-adjusted life-years annually-exceeding established neglected tropical diseases-leptospirosis remains underrecognized as a neglected tropical disease. It affects occupational groups like farmers due to high prevalence in livestock and is spread by rodents in urban settings that have poor sanitation and infrastructure. Although effectively treated with inexpensive antibiotics, neglect of leptospirosis research and development has led to a lack of awareness and unavailability of preventive and diagnostic approaches. This review covers the geographic prevalence, disproportionate impacts on marginalized communities, and opportunities for improving social, economic, and healthcare burdens for patients with leptospirosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.