Evidence map›Paper›PMID 39963580›Full record

ArticleBJUI compass2025

Testosterone levels at diagnosis: A key predictor of overall survival among patients with prostate cancer.

Ilkka Jussila, Juha P Ahtiainen, Eija K Laakkonen, Pirjo Käkelä, Maisa Parviainen, Heikki Pohjolainen, Jarno Aaltonen, Ninamaria Onni, Koskimaa Mikko, Teemu J Murtola and 2 more

Abstract read
In one paragraph

Article in BJUI compass, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ilkka JussilaDepartment of Surgery Wellbeing Services County of Central Finland Jyväskylä Finland.ORCID https://orcid.org/0009-0008-9221-3279
Juha P AhtiainenFaculty of Sport and Health Sciences University of Jyväskylä Jyväskylä Finland.ORCID https://orcid.org/0000-0003-2305-4741
Eija K LaakkonenFaculty of Sport and Health Sciences University of Jyväskylä Jyväskylä Finland.ORCID https://orcid.org/0000-0001-6655-9489
Pirjo KäkeläInstitute of Clinical Medicine University of Eastern Finland Kuopio Finland.ORCID https://orcid.org/0000-0002-6383-0779
Maisa ParviainenSchool of Medicine University of Eastern Finland Kuopio Finland.ORCID https://orcid.org/0009-0000-3720-817X
Heikki PohjolainenSchool of Medicine University of Eastern Finland Kuopio Finland.ORCID https://orcid.org/0009-0009-0801-817X
Jarno AaltonenSchool of Medicine University of Eastern Finland Kuopio Finland.
Ninamaria OnniDepartment of Surgery Wellbeing Services County of Central Finland Jyväskylä Finland.ORCID https://orcid.org/0009-0005-7558-1043
Koskimaa MikkoDepartment of Surgery Wellbeing Services County of Central Finland Jyväskylä Finland.
Teemu J MurtolaFaculty of Medicine and Health Technology Tampere University Tampere Finland.ORCID https://orcid.org/0000-0003-2932-9590
Heini HuhtalaFaculty of Social Sciences Tampere University Tampere Finland.ORCID https://orcid.org/0000-0003-1372-430X
Heikki SeikkulaDepartment of Surgery Wellbeing Services County of Central Finland Jyväskylä Finland.ORCID https://orcid.org/0000-0001-9942-1582

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objective: The exact relationship between testosterone levels at diagnosis and prostate cancer (PCa) prognosis remains inadequately explored. The objective was to determine whether serum testosterone levels at the time of PCa diagnosis are associated with overall survival. Patients and Methods: The study cohort involved 2544 PCa patients, divided into three groups; normal (>10.4 nmol/L), grey zone (8.0-10.4 nmol/L) and low (2.0-8.0 nmol/L) serum testosterone groups. Survival outcomes were analysed using Kaplan-Meier curves and Cox regression models. Results: The analysis revealed an increased risk of death among patients with low testosterone levels compared to those with normal levels in uni- (HR = 1.67, 95% CI: 1.37-2.05, Conclusion: Low testosterone at the time of PCa diagnosis is an independent predictor of overall survival. Findings highlight the potential of testosterone for prognostic evaluation in PCa.

Indexed as

mortality riskprostate cancerprostate cancer prognosisprostate cancer survivalsurvivaltestosterone

Identifiers

PMID39963580
PMCPMC11832296

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.