Evidence map›Paper›PMID 39963520›Full record

ArticleInternational journal of general medicine2025

Correlation of Serum Homocysteine Levels With Various Types of Coronary Syndromes (CS) and In-Hospital Mortality - A Multicenter Study.

Himayat Ullah, Sarwat Huma, Lubna Naeem, Ghulam Yasin, Muhammad Ashraf, Nafisa Tahir, Mohammed Yunus, Hossam Shabana, Abdulrahman H Shalaby, Ahmed Ali Hassan Ali and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Himayat UllahDepartment of Medicine, Shaqra College of Medicine, Shaqra University, Shaqra, Saudi Arabia.ORCID 0000-0001-5533-4591
Sarwat HumaDepartment of Health Professions Education, Health Services Academy, Islamabad, Pakistan.
Lubna NaeemDepartment of Oral Biology, Riphah International University, Islamabad, Pakistan.
Ghulam YasinDepartment of Medicine, Shaqra College of Medicine, Shaqra University, Shaqra, Saudi Arabia.
Muhammad AshrafDepartment of Medicine, Shaqra College of Medicine, Shaqra University, Shaqra, Saudi Arabia.
Nafisa TahirDepartment of Medicine, NSHS, National University of Science and Technology, Islamabad, Pakistan.
Mohammed YunusDepartment of Pathology, Maiwand Teaching Hospital, Kabul University of Medical Sciences (KUMS), Kabul, Afghanistan.
Hossam ShabanaDepartment of Medicine, Shaqra College of Medicine, Shaqra University, Shaqra, Saudi Arabia.ORCID 0000-0003-1674-2722
Abdulrahman H ShalabyInternal Medicine Department, Al-Azhar University, Cairo, Egypt.
Ahmed Ali Hassan AliInternal Medicine Department, Al-Azhar University, Cairo, Egypt.
Mohamed Elwan Mohamed MahmoudInternal Medicine Department, Al-Azhar University, Cairo, Egypt.
Elsayed Mohamed Elsayed TayeeFaculty of Medicine, Helwan University, Cairo, Egypt.
Ahmed Farag Abd Elkader ElbwabInternal Medicine Department, Al-Azhar University, Cairo, Egypt.
Ahmed Mohamed Ewis AlhawyInternal Medicine Department, Al-Azhar University, Cairo, Egypt.ORCID 0009-0003-7784-9918
Ahmed Ahmed Mohamed AbotahaInternal Medicine Department, Al-Azhar University, Cairo, Egypt.
Mahmoud Ezzat AbdelraoufInternal Medicine Department, Al-Azhar University, Cairo, Egypt.
Mohammed S ImamInternal Medicine Department, Al-Azhar University, Cairo, Egypt.
Hossam Aladl Aladl AladlInternal Medicine Department, Al-Azhar University, Cairo, Egypt.
Taiseer Ahmed ShawkyInternal Medicine Department, Al-Azhar University, Cairo, Egypt.
Ashraf Mohammed SaidInternal Medicine Department, Al-Azhar University, Cairo, Egypt.
Mahmoud Saeed MahmoudFaculty of Medicine for Boys, Al-Azhar University, New Damietta, Egypt.
Kazem Mohamed TayeeInternal Medicine Department, Al-Azhar University, Cairo, Egypt.
Reda Fakhry MohamedInternal Medicine Department, Al-Azhar University, Cairo, Egypt.
Ali Hosni FarahatInternal Medicine Department, Al-Azhar University, Cairo, Egypt.
Mohammad Mossaad Abd Allah AlsayyadFaculty of Medicine for Boys, Al-Azhar University, New Damietta, Egypt.
Hesham El Sayed LashinInternal Medicine Department, Al-Azhar University, Cairo, Egypt.
Hani Ismail HamedInternal Medicine Department, Al-Azhar University, Cairo, Egypt.
Hazem Sayed Ahmed Sayed AyoubInternal Medicine Department, Al-Azhar University, Cairo, Egypt.
Ayman Mohamed Salem Ahmed NafieInternal Medicine Department, Al-Azhar University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Coronary artery disease (CAD), clinically manifested as coronary syndrome (CS), is the leading cause of death and a significant contributor to morbidity worldwide. Elevated serum homocysteine levels have been associated with an increased risk of cardiovascular diseases, including CAD. Despite extensive research, the relationship between serum homocysteine and coronary syndromes with related short-term mortality is still under-studied. The main objective of this study is to evaluate the correlation between serum homocysteine levels and various types of CS, as well as in-hospital mortality in these patients. Patients and Methods: This multicenter study included 381 CS patients from Afghanistan, Egypt, and Pakistan tertiary care hospitals. The relation of serum homocysteine levels with different types of CS as well as with in-hospital mortality was measured and analyzed using inferential statistics (ANOVA, Kruskal-Wallis test, Tukey's post-hoc, Pearson correlation, etc.) and regression analysis (Binary regression). Results: Among 381 patients from both genders, 160 were from Pakistan, 130 from Egypt, and 91 from Afghanistan. There was no significant difference in baseline characteristics, like age, gender, homocysteine level, CS type, and mortality, among the three countries ( Conclusion: Serum homocysteine could serve as a valuable biomarker and mortality predictor in CS patients.

Indexed as

cardiac biomarkerscoronary artery disease (CAD)coronary syndromes (CS)risk factors of CADserum homocysteine

Identifiers

PMID39963520
PMCPMC11830938

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.