Evidence map›Paper›PMID 39963446›Full record

ArticleMateria socio-medica2024

Exploring the Role of Ki67 in the Liver of Diabetic Rats.

Suha Khayri Ababneh, Ali Abu Siyam, Moath Alqaraleh, Futoon Abedrabbu Al-Rawashde, Muna M Abbas, Sokiyna Ababneh, Nihad Al-Othman, Islam Khayri Ababneh, Ahed J Alkhatib

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Article in Materia socio-medica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Suha Khayri AbabnehDepartment of Allied Medical Sciences, Zarqa University College, Al-Balqa Applied University, Zarqa, Jordan.
Ali Abu SiyamDepartment of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Jadara University, Irbid, Jordan.
Moath AlqaralehDepartment of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Balqa Applied University, Al-salt, Jordan.
Futoon Abedrabbu Al-RawashdeDepartment of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Balqa Applied University, Al-salt, Jordan.
Muna M AbbasDepartment of Allied Medical Sciences, Zarqa University College, Al-Balqa Applied University, Zarqa, Jordan.
Sokiyna AbabnehDepartment of Allied Medical Sciences, Zarqa University College, Al-Balqa Applied University, Zarqa, Jordan.
Nihad Al-OthmanDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Palestine.
Islam Khayri AbabnehNusaybah Al-Mazniyeh College for Midwifery, Nursing and Allied Medical Professions, Jordan.
Ahed J AlkhatibDepartment of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science and Technology, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diabetes is not a single disease but rather, it is one aspect of metabolic syndrome. The pathologic aspects of diabetes involve cellular changes that need to be understood. Objective: The main objective of this study was to explore the role of Ki67 in the liver of diabetic rats. Methods: The study methodology involved the induction of diabetes in rats using Alloxan (120 mg/kg). A total of 20 albino rats were randomly assigned into two groups control group (N=10) and diabetes group (n=10). Diabetic group received the dose of alloxan, while the control group received similar dose of normal saline. Glucose level was monitored daily. After the end of the experiment (one -month period), all animals were terminated. Blood samples were taken to measure biochemical investigations including glucose, cholesterol, and triglycerides. Liver tissue was excised and washed with normal saline and fixed in buffered formalin (10%). Liver tissue was processed and stained by hematoxylin and eosin for routine histological examination and also stained by immunohistochemistry for Ki67 biomarker. Results: The results revealed the efficacy of the diabetic model. All biochemical investigations were significantly higher in the diabetic group compared with that of control group (p<0.001). Histological studies showed the existence of morphological alterations in cells and fatty changes in the diabetic group compared with the control group. The expression of Ki67 was significantly higher in the diabetic group compared with that in the control group (p=0.011). Conclusion: Taken together, diabetes has adverse effects on the spleen from a histological point of view, and from the expression of Ki67.

Indexed as

Biochemical markersDiabetesHepatic changesKi67 expressionLiver histology

Identifiers

PMID39963446
PMCPMC11830229

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