Case report: dysgeusia, strawberry tongue, and psoriatic eruptions after combination treatment with adalimumab, sulfasalazine, and etoricoxib for ankylosing spondylitis.

Binglin Cui, Jing Lin, Yuanchun Huang, Huachen Zhu, Jinbo Zou, Jiesheng Qin, Hui Pan, Jian Chen

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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Binglin Cui *Department of Pediatrics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.

Jing Lin *Department of Oncology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.

Yuanchun HuangMicrobiology Division, Department of Clinical Microbiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.

Huachen ZhuGuangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases, Joint Institute of Virology (STU/HKU), Shantou University, Shantou, Guangdong, China.

Jinbo ZouDepartment of Dermatology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.

Jiesheng QinDepartment of Otorhinolaryngology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.

Hui PanDepartment of Outpatient, Shantou Longhu People's Hospital, Shantou, Guangdong, China.

Jian ChenDepartment of Neurosurgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Tumor necrosis factor blockers can suppress immune system and lead to various adverse drug reactions, including deaths. We present a rare case of dysgeusia, strawberry tongue, and psoriasis-like eruptions after simultaneous administration of adalimumab, sulfasalazine, and etoricoxib. Case description: A 36 year-old male with ankylosing spondylitis presented with progressive loss of taste for 3 months and rashes on his upper trunk for 5 days. He had been receiving adalimumab, sulfasalazine, and etoricoxib for 9 months. After self-discontinuing the medicines, the rashes gradually subsided. On examination, swollen and red strawberry tongue were noticed. Outcome: He remained in remission during 4 years follow-up. The total course of disease was around 10 months. Discussion: Clinicians should be cautious of the adverse drug reactions/events due to adalimumab, sulfasalazine, and etoricoxib. Rational use of medicines is advocated.

Indexed as

adalimumabadverse drug reactioncase reportdysgeusiapsoriasis-like eruptionstrawberry tongue

Identifiers

PMID39963435

DOI10.3389/fmed.2025.1419922

PMCPMC11830582

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