Evidence map›Paper›PMID 39963419›Full record

ArticleInternational journal of nanomedicine2025

Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy.

Yilu Zheng, Gareth R Williams, Ran Hu, Sen Tong, Jianxiang Xu, Tong Wang, Yanyan Zhang, Junzi Wu, Fan Li, Yingyu Cai and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yilu ZhengCollege of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People's Republic of China.
Gareth R WilliamsUCL School of Pharmacy, University College London, London, WC1N 1AX, UK.
Ran HuCollege of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People's Republic of China.
Sen TongThe Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, 650500, People's Republic of China.
Jianxiang XuCollege of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People's Republic of China.
Tong WangCollege of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People's Republic of China.ORCID 0000-0001-6661-4687
Yanyan ZhangCollege of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People's Republic of China.
Junzi WuThe Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, 650500, People's Republic of China.
Fan LiDepartment of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People's Republic of China.
Yingyu CaiDepartment of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People's Republic of China.
Li-Min ZhuCollege of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People's Republic of China.ORCID 0000-0003-1580-6851

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great promise for anti-tumor therapy. Methods: Here, we report a "nanobomb" that explosively increases Ca content within cells. It can selectively release Ca Results: Under the slightly acidic conditions of the TME, the PAA shell (first lock) breaks down first exposing CaO Discussion: The acid two-step unlocking nanoplatform is a therapeutic modality that combines calcium storm and oxidative damage. The mode triggers apoptosis leading to ICD of tumor cells. The material induces cycle blockade during treatment to inhibit cell proliferation. Robust in vitro and in vivo data demonstrate the efficacy of this approach and CaO

Indexed as

CalciumMitochondriaNanoparticlesNeoplasmsAcrylic ResinsAnimalsAntineoplastic AgentsApoptosisCell Line, TumorCurcuminHumansHydrogen PeroxideMiceMice, Inbred BALB CTumor MicroenvironmentZeolitesAcrylic ResinsAntineoplastic AgentsCalciumcarbopol 940CurcuminHydrogen PeroxideZeolitesanti-cancerCalcium ion loadcontrolled-release nanomaterialspH responsive drug releasereactive oxygen speciestwo-layer protective shell

Identifiers

PMID39963419
PMCPMC11830942

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.