Evidence map›Paper›PMID 39963413›Full record

ArticleFrontiers in cellular and infection microbiology2025

Analysis of intracranial lesions in patients with HIV-associated cryptococcal meningitis.

Wei Song, Li Liu, Tangkai Qi, Zhenyan Wang, Yang Tang, Jianjun Sun, Shuibao Xu, Junyang Yang, Jiangrong Wang, Jun Chen and 2 more

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wei SongDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Li LiuDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Tangkai QiDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Zhenyan WangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yang TangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jianjun SunDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Shuibao XuDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Junyang YangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jiangrong WangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jun ChenDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Renfang ZhangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yinzhong ShenDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Intracranial imaging abnormalities are commonly observed in patients suffering from HIV-associated cryptococcal meningitis, both before and during the treatment period. This study aims to analyze the prevalence, origins, radiological characteristics, treatments, and prognosis of intracranial lesions in patients with HIV-associated cryptococcal meningitis, thereby providing references for future clinical decision-making. Methods: The clinical data of patients diagnosed with HIV-associated cryptococcal meningitis and admitted to the Shanghai Public Health Clinical Centre between 2013 and 2019 were collected. Logistic regression analysis was subsequently conducted to identify potential risk factors associated with the development of intracranial lesions in this patient group. Results: Of 211 patients analyzed, 64.5% (136/211) had intracranial lesions during treatment and follow-up. Initial cranial imaging showed 60% had lesions pre-treatment. Throughout treatment, 32.7% (52/159) developed new or worsened lesions. Mortality rates at 2 weeks, 8 weeks, and 2 years for those with detected lesions were 3%, 7.6%, and 13.2%, respectively. Lesions were primarily caused by Conclusion: Intracranial lesions in HIV-associated cryptococcal meningitis patients are mostly due to Cryptococcus and Mycobacterium infections. They often appear as lacunar infarcts, predominantly in the basal ganglia, and can worsen with treatment initiation, possibly due to higher baseline cytokine levels in cerebrospinal fluid.

Indexed as

AIDS-Related Opportunistic InfectionsBrainHIV InfectionsMeningitis, CryptococcalAdultAgedChinaCryptococcusFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPrognosisRetrospective StudiesRisk Factorscerebrospinal fluidcryptococcal meningitiscytokinesHIVintracranial lesions

Identifiers

PMID39963413
PMCPMC11830730

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