ArticleJournal of cosmetic dermatology2025
T-PRP-DAT Gel: A Novel Material Promotes Adipose Tissue Regeneration.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
10 authors.
Funding
Abstract
backgroundDecellularized adipose tissue (DAT) has emerged as a promising tissue-specific regenerative platform for soft tissue augmentation and reconstruction. Hydrogels are a widely used DAT scaffold format for their injectability and porous structure. While unstable structure and poor vascularization limit the adipose tissue regeneration of DAT gels, this yields significant clinical necessity for solutions to this problem.
methodsBased on collagen-fibrin interpenetrating, we developed an injectable thermosensitive DAT/PRP interpenetrating polymer network (t-DP gel/t-DPI) with the composition of DAT and temperature-controlled platelet-rich plasma (t-PRP). The same volume of t-DP gel and DAT gel were transplanted in a mouse model, and graft volume, weight, adipose tissue regeneration rate, and vascularization were compared.
resultsThe t-DPI showed reinforced stability for the interpenetrating polymer network (IPN) of collagen-fibrin and sustained release of growth factors from the t-PRP, resulting in improved graft volume, weight, adipose tissue regeneration, and vascularization.
conclusionsCompared with traditional DAT gel, t-DP gel promotes adipose tissue regeneration by promoting angiogenesis and stability, and t-DP gel has great potential for future applications in the field of plastic surgery for its simple preparation and regeneration ability.
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