Evidence map›Paper›PMID 39963048›Full record

ArticleMagnetic resonance in medicine2025

Focused ultrasound-induced blood-brain barrier opening: A comparative analysis of permeability quantification based on

Denisa Hývlová, Radovan Jiřík, Jiří Vitouš, Ondřej Macíček, Lucie Krátká, Eva Dražanová, Zenon Starčuk

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Denisa HývlováInstitute of Scientific Instruments, Czech Academy of Sciences, Brno, Czechia.ORCID https://orcid.org/0009-0000-7899-8470
Radovan JiříkInstitute of Scientific Instruments, Czech Academy of Sciences, Brno, Czechia.ORCID https://orcid.org/0000-0003-2555-9428
Jiří VitoušInstitute of Scientific Instruments, Czech Academy of Sciences, Brno, Czechia.ORCID https://orcid.org/0000-0002-9183-8794
Ondřej MacíčekInstitute of Scientific Instruments, Czech Academy of Sciences, Brno, Czechia.ORCID https://orcid.org/0000-0002-0179-5779
Lucie KrátkáInstitute of Scientific Instruments, Czech Academy of Sciences, Brno, Czechia.ORCID https://orcid.org/0000-0003-1104-5215
Eva DražanováInstitute of Scientific Instruments, Czech Academy of Sciences, Brno, Czechia.ORCID https://orcid.org/0000-0003-1844-4489
Zenon StarčukInstitute of Scientific Instruments, Czech Academy of Sciences, Brno, Czechia.ORCID https://orcid.org/0000-0002-1218-0585

Funding

Grantová Agentura České Republiky GA22-10953SMinisterstvo Školství, Mládeže a Tělovýchovy LM2023050
6 · The paper itself

Abstract

purposeFocused ultrasound-induced blood-brain barrier (BBB) opening is a promising method for neurotherapeutic delivery. The standard for quantifying induced BBB permeability is the

methodsWe used the extended Tofts model (ETM) and the two-compartment exchange model (2CXM) to estimate

resultsFor opened BBB,

conclusionBoth

Indexed as

Blood-Brain BarrierMagnetic Resonance ImagingAnimalsBrainComputer SimulationContrast MediaHumansImage Processing, Computer-AssistedPermeabilityContrast MediaBBB openingDCE‐MRIfocused ultrasoundperfusion analysissimulation

Identifiers

PMID39963048
PMCPMC11971499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.