Evidence map›Paper›PMID 39962996›Full record

ArticleInorganic chemistry2025

Ru(II)-Fenamic-Based Complexes as Promising Human Ovarian Antitumor Agents: DNA Interaction, Cellular Uptake, and Three-Dimensional Spheroid Models.

Tamara Teixeira, Marcos V Palmeira-Mello, Pedro Henrique Machado, Carlos A F Moraes, Camila Pinto, Rayane C Costa, Wladimir Badaró, José A Gomes Neto, Javier Ellena, Fillipe Vieira Rocha and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inorganic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Ru-Based NSAIDs as Potential Anticancer Therapeutics.Molecules (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tamara TeixeiraDepartment of Chemistry, Institute of Exact and Biological Sciences, Federal University of Ouro Preto (UFOP), 35402-136 Ouro Preto, Minas Gerais, Brazil.
Marcos V Palmeira-MelloDepartment of Chemistry, Federal University of São Carlos (UFSCar), 13565-905 São Carlos, São Paulo, Brazil.ORCID 0000-0003-2550-5315
Pedro Henrique MachadoDepartment of Chemistry, Institute of Exact and Biological Sciences, Federal University of Ouro Preto (UFOP), 35402-136 Ouro Preto, Minas Gerais, Brazil.
Carlos A F MoraesDepartment of Chemistry, Federal University of São Carlos (UFSCar), 13565-905 São Carlos, São Paulo, Brazil.
Camila PintoInstitute of Physics of São Carlos, University of São Paulo (IFSC/USP), 13566-590 São Carlos, São Paulo, Brazil.
Rayane C CostaInstitute of Chemistry, São Paulo State University (UNESP), 14800-900 Araraquara, São Paulo, Brazil.
Wladimir BadaróInstitute of Chemistry, São Paulo State University (UNESP), 14800-900 Araraquara, São Paulo, Brazil.
José A Gomes NetoInstitute of Chemistry, São Paulo State University (UNESP), 14800-900 Araraquara, São Paulo, Brazil.ORCID 0000-0002-8388-9866
Javier EllenaInstitute of Physics of São Carlos, University of São Paulo (IFSC/USP), 13566-590 São Carlos, São Paulo, Brazil.ORCID 0000-0002-0676-3098
Fillipe Vieira RochaDepartment of Chemistry, Federal University of São Carlos (UFSCar), 13565-905 São Carlos, São Paulo, Brazil.ORCID 0000-0002-5117-871X
Alzir A BatistaDepartment of Chemistry, Federal University of São Carlos (UFSCar), 13565-905 São Carlos, São Paulo, Brazil.
Rodrigo S CorreaDepartment of Chemistry, Institute of Exact and Biological Sciences, Federal University of Ouro Preto (UFOP), 35402-136 Ouro Preto, Minas Gerais, Brazil.ORCID 0000-0003-2783-0816

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer resistance to chemotherapeutic agents such as cisplatin presents a significant challenge, leading to treatment failure and poor outcomes. Novel metal-based compounds offer a promising strategy to overcome drug resistance and to enhance efficacy. Four Ru(II) complexes with fenamic acid derivatives were synthesized and characterized: [Ru(L)(bipy)(dppp)]PF

Indexed as

Antineoplastic AgentsCoordination ComplexesDNAOvarian NeoplasmsRutheniumCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorFemaleHumansMolecular StructureSpheroids, CellularStructure-Activity RelationshipAntineoplastic AgentsCoordination ComplexesDNARuthenium

Identifiers

PMID39962996
PMCPMC11884657

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.