Evidence map›Paper›PMID 39962970›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Inhibitors of soluble epoxide hydrolase and cGAS/STING repair defects in amyloid-β clearance underlying vascular complications of Alzheimer's disease.

Milan Fiala, Bruce D Hammock, Sung Hee Hwang, Julian Whitelegge, Ketema Paul, Karolina Elżbieta Kaczor-Urbanowicz, Andrzej Urbanowicz, Santosh Kesari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Milan FialaDepartment of Integrative Biology and Physiology, UCLA School of Medicine, Los Angeles, CA, USA.ORCID 0009-0008-5212-0123
Bruce D HammockDepartment of Entomology and Nematology, UC Davis Comprehensive Cancer Center University of California-Davis, Davis, CA, USA.
Sung Hee HwangDepartment of Entomology and Nematology, UC Davis Comprehensive Cancer Center University of California-Davis, Davis, CA, USA.ORCID 0000-0002-9891-928X
Julian WhiteleggeDepartment of Psychiatry, UCLA School of Medicine, Los Angeles, CA, USA.ORCID 0000-0003-2763-7733
Ketema PaulDepartment of Integrative Biology and Physiology, UCLA School of Medicine, Los Angeles, CA, USA.ORCID 0000-0003-0226-9559
Karolina Elżbieta Kaczor-UrbanowiczCenter for Oral and Head/Neck Oncology Research, Biosystems and Function, UCLA School of Dentistry, University of California at Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-9243-3652
Andrzej UrbanowiczCenter for Oral and Head/Neck Oncology Research, Biosystems and Function, UCLA School of Dentistry, University of California at Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-8376-1603
Santosh KesariProvidence Saint John's Health Center, Santa Monica, CA, USA.ORCID 0000-0003-3772-6000

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1M
UC Davis CounterACT Center of Excellence: Developing Therapeutic Strategies for Mitigating the Chronic Neurological Consequences of Acute Organophosphate IntoxicationU54NS127758 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Gene Gabriel Gurkoff · 2022 to 2026
$17.2M
Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human healthR35ES030443 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORISSEAU, CHRISTOPHE HP · 2019 to 2025
$5.8M
The impact of sex chromosomes on the ability to recover from sleep lossR01NS078410 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PAUL, KETEMA N · 2012 to 2025
$3.7M
Multiphoton Microscope for Deep Tissue ImagingS10OD025017 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BENTOLILA, LAURENT A. · 2018 to 2018
$599k
NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R35 ES030443NIH HHS S10 OD025017NINDS NIH HHS R01 NS078410NINDS NIH HHS U54 NS127758
6 · The paper itself

Abstract

BackgroundAlzheimer's disease (AD) and its monoclonal antibody therapies are associated with brain vasculitis and amyloid-related imaging abnormalities. The naturally-formed epoxides (EpFAs) of polyunsaturated fatty acids (PUFAs), such as 11,12-epoxyeicosatetraenoic acid (EEQ), are anti-inflammatory and pro-resolution mediators, which are increased by dietary supplementation with ω-3 PUFAs. EpFAs are, however, enzymatically hydrolyzed by soluble epoxide hydrolase (sEH) in AD patients' macrophages in vivo and in vitro

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesEnzyme InhibitorsEpoxide HydrolasesMembrane ProteinsAgedBrainFemaleHumansMacrophagesMalePeptide FragmentsSTING ProteinAmyloid beta-Peptidesamyloid beta-protein (1-42)Enzyme InhibitorsEpoxide HydrolasesMembrane ProteinsPeptide FragmentsSTING1 protein, humanSTING ProteinAlzheimer's diseaseamyloid-betaEC5026H-151monocytes/macrophagessoluble epoxide hydrolaseTPPUvascular complications

Identifiers

PMID39962970
PMCPMC11969680

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.