Synthesis, Characterization and Preliminary Screening of New N-Substituted -8-Methyl-4-Hydroxy-2-Quinolone -3-Carboxamides as Potential Anticancer Agents.

Dania Altaher, Hiba Zalloum, Kamal Sweidan, Dima A Sabbah, Husam AlSalamat, Mahmoud Sunjuk, Reem Isleem

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Article in Current organic synthesis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Dania AltaherDepartment of Chemistry, The University of Jordan, Amman, 11942, Jordan.

Hiba ZalloumHamdi Mango Research Centre for Scientific Research, The University of Jordan, Amman, 11942, Jordan.

Kamal SweidanDepartment of Chemistry, The University of Jordan, Amman, 11942, Jordan.

Dima A SabbahDepartment of Pharmacy, Faculty of Pharmacy, Al- Zaytoonah University of Jordan, Amman, 11733, Jordan.

Husam AlSalamatHamdi Mango Research Centre for Scientific Research, The University of Jordan, Amman, 11942, Jordan.

Mahmoud SunjukDepartment of Chemistry, Faculty of Science, The Hashemite University, Zarqa, 13133, Jordan.

Reem IsleemDepartment of Pharmacy, Faculty of Pharmacy, Al- Zaytoonah University of Jordan, Amman, 11733, Jordan.

Funding

University of Jordan, Deanship of Scientific Research 2385

6 · The paper itself

Abstract

introductionA new series of 4-hydroxy-8-methyl-2-oxo-1,2-dihydroquinoline-3- carboxamide derivatives has been synthesized in good yields, followed by complete characterization using 1D-NMR, 2D-NMR, and IR techniques.

methodsThe final products contain amide, hydroxyl, and aromatic functional groups that usually show significant bioactivity. The target products have been examined towards three cancer cell lines, namely colorectal cancer cell line (HCT116), breast cancer cell line (MCF-7), and leukemia cell line (K562) in addition to the fibroblast cells, that were used as a model for normal human tissue.

resultsThe anticancer results signified that compound 6 showed the most activity in the series accomplished with IC

Indexed as

Antineoplastic AgentsQuinolonesCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHCT116 CellsHumansMCF-7 CellsMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsQuinolonesAnticancerHCT116K562MCF-7N-Substituted -8-Methyl-4-Hydroxy-2-Quinolone -3-Carboxamides.quinolone

Identifiers

PMID39962962

DOI10.3390/molecules25225348

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.