Evidence map›Paper›PMID 39962707›Full record

ReviewCurrent medicinal chemistry2025

Exploring the Therapeutic Potential of Vesicular Nanocarrier Systems for Elimination of Skin Cancer.

Lalit Kumar, Ritesh Rana, Komal Komal, Vikas Aggarwal, Sumit Kumar, Neeraj Choudhary, Aafreen Fathima H, Sorabh Lakhanpal

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lalit KumarDepartment of Pharmaceutics, GNA School of Pharmacy, GNA University, Phagwara, Punjab, 144401, India.
Ritesh RanaDepartment of Pharmaceutical Sciences (Pharmaceutics), Himachal Institute of Pharmaceutical Education and Research (HIPER), Bela-Nadaun, District-Hamirpur, H.P. 177033, India.
Komal KomalDepartment of Pharmacology, Chandigarh College of Pharmacy, Landran, Sahibzada Ajit Singh Nagar, Punjab, 140307, India.
Vikas AggarwalSenior Pharmacovigilance Specialist, Continuum India LLP, 3rd Floor, Tower F DLF Building, Chandigarh Technology Park, Chandigarh, 160101, India.
Sumit KumarDepartment of Pharmaceutical Chemistry, Gautam College of Pharmacy, District-Hamirpur, H.P. 177001, India.
Neeraj ChoudharyDepartment of Pharmacognosy, GNA School of Pharmacy, GNA University, Phagwara, Punjab, 144401, India.
Aafreen Fathima HCenter for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, 602105, India.
Sorabh LakhanpalSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkin cancer, a common malignancy worldwide, has increased incidence and mortality. Thus, it is a public health issue and a significant illness burden, which increases treatment costs. Chemotherapy and surgery are used to treat skin cancer. However, conventional skin cancer treatments have several limitations, demanding the development of innovative, safe, and effective methods. To overcome these limitations of conventional topical dosage forms, many nanocarriers have been developed and tested for the targeted delivery of anticancer drugs.

objectiveThe main objective of the present review was to discuss the utility of various vesicular nanocarrier systems to deliver anticancer drugs following topical administration to treat skin cancer.

methodsFor this review article, we scoured the scholarly literature using Science Direct, Google Scholar, and PubMed. DISCUSSION: The vesicular drug delivery system has been intensively explored and developed as an alternative to conventional skin cancer drug delivery systems, especially for melanoma. They improve the penetration of anticancer drugs via the skin, reaching the cancer area with enough and killing cancer cells. Vesicles minimize skin irritation and drug degradation. This improves therapy efficacy and reduces systemic toxicity.

conclusionUtilizing the vesicular drug delivery system shows promise in treating skin cancer. Therefore, further research and inquiries are necessary to explore the therapeutic potential of these substances in treating skin cancer, intending to develop a personalized, efficient, and secure therapy approach for patients with this condition.

Indexed as

Antineoplastic AgentsDrug CarriersNanoparticlesSkin NeoplasmsAnimalsDrug Delivery SystemsHumansAntineoplastic AgentsDrug Carriersanticancer drugs.chemotherapyConventionalnanocarrierskin cancertherapeutic potential

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.