Evidence map›Paper›PMID 39962508›Full record

ReviewLipids in health and disease2025

Crosstalk between renin and arachidonic acid (and its metabolites).

Undurti N Das, Ahmet Hacimüftüoglu, Erol Akpinar, Mustafa Gul, A M Abd El-Aty

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. AA in Rheumatoid Arthritis and Lupus.Reviews of physiology, biochemistry and pharmacology · 2027
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Undurti N DasUND Life Sciences, 2221 NW 5th St, Battle ground, WA, 98604, USA. undurti@hotmail.com.
Ahmet HacimüftüogluDepartment of Medical Pharmacology, Medical Faculty, Ataturk University, Erzurum, 25240, Turkey.
Erol AkpinarDepartment of Medical Pharmacology, Medical Faculty, Ataturk University, Erzurum, 25240, Turkey.
Mustafa GulDepartment of Physiology, Faculty of Medicine, Ataturk University, Erzurum, 25240, Turkey.
A M Abd El-AtyDepartment of Medical Pharmacology, Medical Faculty, Ataturk University, Erzurum, 25240, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renin plays a significant role in the regulation of blood pressure and fluid volume by modulating the renin‒angiotensin‒aldosterone (RAAS) system. Renin suppression reduces serum aldosterone levels and lowers blood pressure in addition to preserving renal function. However, exactly how renin synthesis and action are regulated and how renin suppression preserves renal function are not clear. We propose that arachidonic acid (AA) and its metabolites control renin synthesis, secretion, and action by virtue of its (AA) anti-inflammatory, cytoprotective actions and ability to regulate the secretion of renin. These findings suggest that direct renin suppression results in changes in AA metabolism. This proposal implies that AA and its metabolites may be developed as potential drugs to prevent and manage hypertension and preserve renal function.

Indexed as

Arachidonic AcidHypertensionReninAldosteroneAnimalsBlood PressureHumansKidneyRenin-Angiotensin SystemAldosteroneArachidonic AcidReninArachidonic acidInflammationNeurotransmittersNitric oxideReninRenin-angiotensin-aldosterone system

Identifiers

PMID39962508
PMCPMC11831833

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.