SynthesisBMC endocrine disorders2025
Burden of peripheral artery disease and risk factors among patients with diabetes mellitus in sub-Saharan Africa: a systematic review and meta-analysis.
Synthesis in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Screening practices and risk factors for diabetic foot complications among patients with diabetes at a tertiary centre in Riyadh, Saudi Arabia.Journal of family medicine and primary care · 2026Article
- Article
- Global Burden, Attributable Risk Factors, and Future Projections of Lower Extremity Peripheral Arterial Disease Among Postmenopausal Women.International journal of women's health · 2026Article
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6 authors.
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Abstract
backgroundDiabetes is a non-communicable disease that presents a substantial public health challenge on a global scale. Peripheral artery disease is a significant macrovascular problem in diabetes mellitus characterized by atherosclerotic narrowing of the artery in the lower extremities, leading to compromised distal perfusion, primarily caused by atherosclerosis, and resulting in impaired functional capacity. Although existing studies on, peripheral artery disease among patients with diabetes mellitus are available, the results have been inconsistent.
objectiveTo determine the pooled burden and associated factors of peripheral artery disease among patients with diabetes mellitus in sub-Saharan Africa.
methodsA systematic review and meta-analysis were performed following the guidelines established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. To identify papers published in English up to August 10, 2024, the electronic databases of Medline, Science Direct, Excerpta Medica Database, Cochrane Library, African Journals Online, and Google Scholar were searched. A random-effects model was employed to estimate the pooled prevalence and associated factors of peripheral artery disease. To test for heterogeneity between studies and publication bias, forest plots and funnel plots were used.
resultsThis study revealed that the pooled prevalence of peripheral artery disease among patients with diabetes mellitus was 32.97% (95% CI 29.7, 36.24), reflecting the significant impact of diabetes mellitus on vascular health. Age (OR = 2.51, 95% CI = 3.41-12.09), increased level of low density lipoprotein (OR = 1.64, 95% CI = 1.05-13.09), BMI (OR = 3.03, 95% CI = 1.74-7.56), and illness duration exceeding 10 years (OR = 2.44, 95% CI = 1.12-5.13), were the significant predictors.
conclusionDespite the alarming prevalence of peripheral artery disease among patients with diabetes in sub-Saharan Africa, it remains underdiagnosed; therefore, increased awareness, proactive screening initiatives, and management strategies within the clinical setting are necessary. CLINICAL TRIAL NUMBER: Not applicable. PROSPERO: CRD42024594577.
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