Evidence map›Paper›PMID 39962308›Full record

ArticleScientific reports2025

Investigating the causal relationship between the plasma lipidome and cholangiocarcinoma mediated by immune cells: a mediation Mendelian randomization study.

Heng Yin, Keli Yang, Yan Lou, Yaling Zhao

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Heng Yin *Department of Hepatology, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
Keli Yang *Department of Hepatology, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
Yan LouDepartment of Hepatology, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
Yaling ZhaoSchool of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China. yhul196@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The plasma lipidome and immune cells are instrumental in shaping the health profile of an organism, and their influence on diseases is profound. However, the intricate interactions between cholangiocarcinoma (CCA) and these physiological components have yet to be comprehensively explored. Employing Mendelian randomization (MR), our study delved into the causal links among immune cells, the lipidome, and CCA. The research design meticulously considered both the direct associations and the mediating roles of immune cells within the complex interplay between the lipidome and CCA. Our analysis uncovered significant correlations between the levels of Sphingomyelin (d34:1), Phosphatidylcholine (0-16:0, 22:5) and Sterol ester (27:1/16:0) and CCA. Moreover, we have pinpointed various immune cells that play a mediating role in the impact of the lipidome on CCA. For example, Sphingomyelin (d34:1) can impact CCA through the IgD on IgD

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaLipidomicsLipidsB-LymphocytesHumansMendelian Randomization AnalysisSphingomyelinsLipidsSphingomyelinsCholangiocarcinomaImmune cellsMediation analysisMendelian randomizationPlasma lipidome

Identifiers

PMID39962308
PMCPMC11832772

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