ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging
High-Field Diffusion Tensor Imaging of Median, Tibial, and Sural Nerves in Type 2 Diabetes With Morphometric Analysis.
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Preoperative BUN-to-Albumin Ratio Is Independently Associated with Major Reamputation After Distal Amputation in Diabetic Foot: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Extracellular Matrix Remodelling in the Human Sural Nerve in Peripheral Vascular Disease.Medicina (Kaunas, Lithuania) · 2026Article
- Predictors of Peripheral Neuropathy in Metabolic Disease: A Multivariable Analysis Incorporating the Toronto Clinical Scoring System and Sudomotor Assessment.Medicina (Kaunas, Lithuania) · 2026Article
- Outcomes and Laboratory Predictors of Complications Following Diabetic Foot Amputations: A Ten-Year Tertiary Care-Center Experience.Medicina (Kaunas, Lithuania) · 2026Article
- Evaluation of Neutrophil-to-Lymphocyte Ratio and CRP-to-Albumin Ratio in the Risk Stratification of Diabetic Foot Infection Severity.Medicina (Kaunas, Lithuania) · 2026Article
- Plasma Mucin-1 as a Potential Biomarker for Diabetic Peripheral Neuropathy in Type 2 Diabetes.Biomolecules · 2026Article
- The Effect of RAGE-Diaph1 Signaling Inhibition on the Progression of Peripheral Neuropathy in Diabetic Mice.International journal of molecular sciences · 2025Article
- Sex Differences in Cardiovascular Risk and Diabetic Polyneuropathy: A Single-Center Retrospective Study in North-Eastern Hungary.Journal of clinical medicine · 2025Article
- Sensitivity of Diffusion Tensor Imaging for Assessing Injury Severity in a Rat Model of Isolated Diffuse Axonal Injury: Comparison with Histology and Neurological Assessment.International journal of molecular sciences · 2025Article
- Effect of Pandemic on the Clinical Status of Patients Admitted to Hospital for Diabetic Foot: A Retrospective Study.Journal of clinical medicine · 2025Article
- The Impact of Biodex Balance on Improving Coordination and Static Balance in Patients with Diabetic Peripheral Neuropathy.Life (Basel, Switzerland) · 2025Article
- Percutaneous Tibial Nerve Stimulation for Neurogenic Bladder Due to Severe Lumbosacral Disc Herniation.Journal of clinical medicine · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
background and purposeThe primary objective was to compare diffusion tensor imaging (DTI) scalar parameters of peripheral nerves between subjects with type 2 diabetes mellitus (T2DM) and those without diabetes. Secondarily, we aimed to correlate DTI scalar parameters with nerve morphometric properties.
methodsMedian, tibial, and sural nerves were harvested from 34 male cadavers (17 T2DM, 17 nondiabetic). Each nerve was divided into three segments. The initial segment was scanned using 9.4 Tesla MRI system (three-dimensional pulsed-gradient spin-echo sequence). DTI scalars were calculated from region-average diffusion-weighted signals. Second segment was optically cleared, acquired with optical projection tomography (OPT), and analyzed for morphometrical properties. Toluidine-stained sections were prepared from last segment, and axon- and myelin-related properties were evaluated.
resultsDTI scalar parameters of median and tibial nerves were comparable between the groups, while sural nerves of T2DM exhibited on average 41% higher mean diffusivity (MD) (p = 0.03), 38% higher radial diffusivity (RD) (p = 0.03), and 27% lower fractional anisotropy (FA) (p = 0.005). Significant differences in toluidine-evaluated parameters of sural nerves were observed between the groups, with a positive correlation between FA with fiber density (p = 0.0001) and with myelin proportion (p < 0.0001) and an inverse correlation between RD and myelin proportion (p = 0.003). OPT-measured morphometric properties did not correlate with DTI scalar parameters.
conclusionsHigh-field DTI shows promise as an imaging technique for detecting axonal and myelin-related changes in small sural nerves ex vivo. The reduced fiber density and decreased myelin content, which can be observed in T2DM, likely contribute to observed FA reduction and increased MD/RD.
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