ArticleScientific reports2025
Excessive lymph node dissection increases postoperative cardiovascular disease risk in non-small cell lung cancer patients.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Prognostic Impact of Inadequate Lymph Node Evaluation in Early-Stage Lung Adenocarcinoma with Micropapillary or Solid Components.Annals of surgical oncology · 2026Article
- Impact of lymph node yield on survival of patients with metastatic esophageal cancer: a population-based retrospective study.Discover oncology · 2025Article
- Identification of the lymph node metastasis atlas and optimal lymph node dissection strategy in patients with resectable lung invasive mucinous adenocarcinoma: a real-world multicenter study.Military Medical Research · 2025Article
- Development and internal validation of a nomogram to predict postoperative atrial fibrillation in elderly patients with lung cancer.Journal of thoracic disease · 2025Article
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6 authors.
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Abstract
Heart disease is the second leading cause of death in lung cancer (LC) patients, with postoperative cardiovascular disease (CVD) commonly linked to lymph node dissection (LND). This study aimed to clarify the optimal number of lymph nodes (LNs) to be dissected by investigating the impact of LND on CVD related death in patients with surgically resected non-small cell lung cancer (NSCLC). We analyzed data from the Surveillance, Epidemiology, and End Results (SEER) database for a total of 154,566 patients with stage IA-IIIA NSCLC that underwent curative surgery from 2000 to 2020, and further validated using clinical data from a single-center cohort. For patients with negative lymph nodes, the optimal LND threshold was 3 without RT (SHR = 0.909, 95% CI: 0.841-0.982, p = 0.016) and 11 with RT (SHR = 0.877, 95% CI: 0.757-1.015, p = 0.079). For positive lymph nodes (PLNs), 0.53 was the structural breakpoint for the PLNs ratio (p < 0.001). Data from a single-center cohort of 200 patients showed that with LND between 10 and 12, cardiovascular events significantly increased (OR = 18.870, p = 0.044). Excessive dissection of immune-functioning LNs may contribute to the occurrence of death from heart disease and amplify the effects of RT on cardiovascular mortality.
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